Some Haematological Changes in Trypanosoma-Infected Albino Rats When Treated with Zingiber Officinale and Curcuma Longa
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Abstract
The study determined the effect of Zingiber officinale and Curcuma longa on the liver function of albino rats
infected by Trypanosoma brucei brucei. Acclimated five to six-weekold male rats were divided into five groups
(A – E), each with three replicates. Group A; positive control (uninfected and untreated), Group B; negative control
(infected and untreated), Group C (treated with 10 g of ginger meal mixed with 1 kg of chick mash), Group D
(treated with 10 g of turmeric meal mixed with 1 kg of chick mash) and Group E (treated with 5 g each of ginger
and turmeric in 1 kg of chick mash). The data were subjected to one-way ANOVA, and tested at p>0.05. Results
showed that while all the treatment groups (C – E) maintained a high PCV, there was no significant difference between
the experimental groups and positive control; WBC showed significant difference from the other groups,
with the ginger treated group C, showing no significant difference with the negative group B; while the combined
group E and turmeric treated group D are significantly different from B and C. RBC results showed that ginger
and turmeric influenced the experimental groups; with ginger and turmeric treated groups C and D showing
great improvement; although there exist a significant different between them and the positive control. At the
levels administered, ginger and turmeric supplements caused minimal changes in the haematological indices of
rats. Based on these results, there is a need for further research; on higher dosages of ginger and turmeric supplements,
and the use of other medicinal herbs that may ameliorate physiological stress caused by Trypanosoma
infection in the haematological indices of rats.
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