Chromatographic Analysis of General Otc Anti-Allergic Drug: Cetirizine

Abstract

Cetirizine as general OTC anti-allergic drug was evaluated through paper chromatography. Twelve cetirizine

compositions were analysed wherein each tablet and syrups were six in number. Seven solvent systems

were experimented from which chloroform and methanol in ratio 50:50 proved to be best solvent system

for both cetirizine tablet and syrup compositions. Other solvent system that showed clear separation of

spots were n-hexane, toluene and diethyl ether in ratio 65:25:10 and acetone and methanol in ratio 90:10 for

tablet and syrup preparations respectively. Iodine fuming technique and UV radiations were also utilized for

visualising some unidentified and invisible spots during the examination procedures.