The Histological Alteration of Proximal Part of Aorta Exposed to (MSG) and Protective Effect of an a Lipoic Acid (ALA) in Male Rabbits

Abstract

Background. Monosodium Glutamate is one of the most world’s most widely used food additives. Its toxic

effect have been shown in numerous animal studies, in which study MSG effects on cardiovascular system,

therefore, This study was aimed to investigate the effect of alpha lipoic acid(ALA) on the damage in the

large blood vessels induce by Mono sodium glutamate. Thirty two male rabbits was divided equally and

randomly into four groups as following. Control group in which rabbits where fed with normal diet without

supplementation, second group was gived MSG orally (8mg/kg.BW), While animals of third group were

given ALA orally (60mg/kg.BW) while animal in fourth group were given orally (MSG 8mg/kg.bw and

ALA 60mg/kg.bw), all treatment are extended to 8 weeks. The outcomes of research revealed a significant

increased (p<0.05) in aortic medial layer thickness in animals administration of MSG in a comparesion

with control and groups treated and distortion structure of laminar fibers, endothelial cells lost normal

squamous. In addition, there is a significant decreased (p<0.05) in medial tunica thicken in animals used

ALA combination with MSG, so we noted return the disarranged of architecture tissue near.