Salivary Zinc level and Taste Detection Thresholds in Hypertensive Patients on Amlodipine and on Losartan (A Comparative Study)
DOI:
https://doi.org/10.37506/ijfmt.v14i2.10557Keywords:
Taste Detection Thresholds, Hypertensive, Amlodipine, Losartan, ZincAbstract
High blood pressure (hypertension) is one of greatest risk factors for cardiovascular disease,which
is a remarkable cause of morbidity and mortality worldwide. The outcome of hypertension (HTN) and
cardiovascular disease (CVD) is influenced by a wide variation of risk factors like use of tobacco; excessive
alcohol consumption; unhealthy diet, few physical activity ,overweight and obesity; high blood glucose,
and abnormal blood lipids. The objectives of this study were to evaluate taste detection thresholds (of
four basic tastes) of hypertensive patients on Amlodipine 5 mg and on Losartan 50 mg. And to estimate
Zinc level in saliva of those patients and compare it with control subjects. A total of 90 subjects were
incorporated in this study they were divided into three groups: 1-Thirty patients on Amlodipine (5mg)
2-Thirty patients on Losartan (50mg) and 3- Thirty healthy control subjects. Unstimulated whole saliva was
collected from all subjects including in this study. Volume of 5 ml of each taste gradient solution,was offered
to the participants. The samples were subjected to biomechanical analysis to estimate zinc level by using
the atomic absorption spectrophotometer.The result showed that the taste detection threshold of sucrose and
sault were significantly higher in patients on Amlodipine and on Losartan treatment than in control subjects.
While the taste detection threshold of sour and bitter showed no significant differences between the study
groups. Also there is un alteration in salivary Zinc, Zinc in patients on Amlodipine and on Losartan was
significantly lower compared to control group.
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