Effect of Purple Leaf Extract (Graptophyllum Pictum (L.) Griff) on the Number of Macrophage Cells in Pulp Perforation

Abstract

Background: Purple leaf (Graptophyllum pictum (L.) Griff) is one of Indonesia’s traditional medicinal

plants, which has anti-inflammatory properties which is expected to stop the inflammation of the pulp

accompanied by perforation. Purpose: To determine the effect of giving purple leaves (Graptophyllum

pictum (L.) Griff) to the number of macrophage cells in pulp perforation. Method: The study used 24 Wistar

rats divided into four groups, namely control (K), and 3 treatment groups P1, P2, P3. Each group consisted

of 6 rats prepared, then P1 was given 10% purple leaf extract, P2 was given 15% purple leaf extract, P3

was given 20% purple leaf extract. On the 3rd day, the Wistar rat was sacrificed and continued with the

preparation of HPA. Calculation of the number of macrophages was obtained from the One-way ANOVA

test. Results: There were significant differences between the control and treatment groups (K with P1, P2,

P3), on the results of the One-way ANOVA difference-result test (p <0.05) Conclusion: Purple leaf extract

(Graptophyllum pictum (L.) Griff) affected increasing the number of macrophage cells in pulp perforation

after the 3rd day of treatment.