Analysis of the Moringa oleifera Seed Oil Extract on Insulin Level in Alloxan-Induced Diabetic Rat (Rattus norvegicus)

Abstract

Moringa oleifera is a plant that can be used and grown intensively in several Southeast Asian countries. This

study aims to determine the effect of Moringa oleifera seed oil extract on the levels of the insulin and blood

glucose levels of Rattus norvegicus induced by alloxan. This study used 30 female Wistar white rats induced

by alloxan. Rats were divided into 6 groups. Groups 3 to 6 were injected 100, 200, 300, 400 mg/kg BW

extract of Moringa oleifera seed oil, respectively. Group 1 neither had alloxan induction nor treatment while

group 2 had been induced alloxan but no treatment. Data were analyzed using the Kruskal-Wallis test with

a significance level of 0.05. The results showed that there was no effect of Moringa oleifera seed oil extract

on insulin level (p value = 0.161). Conversely, there was an effect on blood glucose levels in alloxan-induced

Rattus norvegicus (p value = 0.036).