Relationship Between High Sensitivity TNF-? WITH clinical outcome During Admission In Acute Ischemic Stroke

Abstract

Background : Tumor necrosis factor alpha (TNF-?), together with other pro-inflammatory cytokines such
as Interleukin-1b (IL-1b), IL- 6 and IL-8, play a role in the ischemic injury of the central nervous system.
TNF-? has adverse effects on ischemic brain tissue. The mechanism generated is a multicomplex process. In
other studies, an increase in TNF-? can actually have neuroprotective effects. This study aims to determine
the relation between the levels of the High Sensitivity TNF-? with clinical outcome in acute ischemic stroke.
Method : Thirty patients with acute ischemic stroke patients who admitted in Dr. Soetomo hospital Surabaya
during the period December 2011 to February 2012. 2 cc of vein blood for examination High sensitivity
TNF-? was drawn during admission from acute ischemic stroke. Clinical outcome in acute stroke was
measured by NIHSS score.
Results: From 30 research samples, the mean age of patients was 59.53 ± 11.51 years. The mean High
Sensitivity TNF-? level in the study subjects was 2 ± 0.99 pg / ml. NIHSS examination showed the median
value of the NIHSS was 5 with a range of 2-19. There is a correlation but not statistically significant with
the strength is very weak between High Sensitivity TNF-? with the NIHSS in patients with acute thrombotic
stroke (r = 0.100 and p = 0.600).
Conclusion: There is relationship between serum levels of High sensitivity TNF-? with clinical outcome in
acute ischemic stroke patients.