Guggulsterone Suppresses Ovalbumin- Induced Inflammation in Rat Asthmatic Model

Authors

  • Zainab H. Ahmed1 , Munaf H. Zalzala2, Manal A. Ibrahim1

DOI:

https://doi.org/10.37506/ijfmt.v15i1.13759

Keywords:

gugglsterone, asthma, anti-inflammatory activity , NF-kappaB

Abstract

Background: Asthma is an inflammatory airway disease, which is characteristic by wheezing, chest
tightness, dyspnea and cough, all symptoms that are occupied with obstruction of respiratory airway. Aim:
investigate guggulsterone activity on improve inflammatory events that associated with asthma. Method:
48 healthy rats (albino, male) divided to 6 groups, rats were sensitized with OVA and preparation lung tissue
homogenate for measurement of inflammatory parameters by ELISA and RT-PCR. Also, preparation of lung
tissue for histopathological examination. Results: All parameters are significant reduction in treated group
with guggulsterone than sensitized group. Also, gugglsterone-treated group’s slides with less inflammatory
signs compared to sensitized group slide. Conclusion: Guggulsterone improve inflammatory events that
associated with asthma.

Author Biography

  • Zainab H. Ahmed1 , Munaf H. Zalzala2, Manal A. Ibrahim1

    1
    Lecturer, Department of Pharmacology and Toxicology, College of Pharmacy, University of Basra, Basra, Iraq,
    2 Assist of Professor, Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad,
    Baghdad, Iraq

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Published

2020-12-31

Issue

Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology

Section

Articles

License

https://creativecommons.org/licenses/by-nc/2.0/deed.en

How to Cite

Guggulsterone Suppresses Ovalbumin- Induced Inflammation in Rat Asthmatic Model . (2020). Indian Journal of Forensic Medicine & Toxicology, 15(1), 2388-2395. https://doi.org/10.37506/ijfmt.v15i1.13759