Evaluations of Inflammatory Status in Chronic Renal Failure Patients Undergoing Hemodialysis and Conservative Treatment

Abstract

Introduction: - Chronic inflammation is a basic feature of end stage kidney disease and is associated with
increasing risk of mortality and morbidity in patients undergoing dialysis.The aim: - the study amid to
evaluate white blood cells and IL-6 in patients undergoing hemodialysis and without hemodialysis. Methods
and Subjects:- The study was designed on 106 patients with chronic renal failure age range (20-69years).
The patients divided in two groups according to treatment, 40 patients with conservative treatment and
66 patients with hemodialysis treatment. IL-6 were determined by using a commercially available ELISA
Micro wells kit. Total white blood cells count and differential count were determined by using an automated
hematology autoanlyzer XT2000i. Results:- showed a significant (p<0.05) decrease of total white blood
cells count, neutrophils, lymphocytes, monocytes, eosinophils and basophils in hemodialytic group when
compared with conservative group. But IL-6 levels was higher significantly (p<0.01) in hemodialytic group
when compared with conservative group. Conclusion: - hemodialysis session impaired immune system and
activated anti-inflammatory factors.