Thyroid Carcinoma Patients Correlated With Cytomegalovirus by using Insitu Hybridization

Abstract

Worldwide, the most common cancer-related deaths and poses one of the top ten most risk cancers globally
in many countries, is the thyroid carcinoma. In human cancers, there are important factor associated with
it . The viral agent is one of them which is involved in the spread of tumors, including thyroid cancers. So,
the present study was designed to determine the relationship between Cytomegalovirus infection with some
Iraqi patients who suffer from the thyroid carcinoma in tissue cancer from different site (papillary, follicular
and lymph node) by using In Situ Hybridization Technique, related to their age, gender, site distribution,
histological grade and the tumor stage. The sixty biopsies were randomly collected during the period between
June 2017 until October 2018,CMV was detected in(28.3%)(17 out of 60 patients, the mean age was 39
years old, ranged between ( 27-72) years old, female to male ratio was (1.3 : 1) with 34 women and 26 men.
The most of these cases were papillary carcinoma 39, followed by follicular 13 and the rest 8 cases were at
the lymph node. Histological grades that involved were 37 well differentiated, 18 were poorly differentiated,
and 5 were moderately differentiated. Tumor staging included 43 patients who fall in stage I and II, while
the rest 17 patients fall in stage III and IV. Regarding to the positive results, CMV correlates in a highly
significant association with each of (age, gender, grading, tumor stage, and site distribution at p<0.01).
It could be concluded from that the in situ hybridization is useful in the clinical evaluation of patients with
thyroid carcinoma. And suggested that the viral agent cytomegalovirus is involved in thyroid carcinogenesis
and may play an important role in the malignant transformation of thyroid cancer.