Evaluation of Lipocalin-2 and Visfatin, and Vitamin (D,C, and E) in Serum of Diabetic Patients with Chronic Periodontitis

Abstract

Objective: The aim of the present study is to verify the hypothesis that salivary and serum lipocalin-2
and visfatin, and vitamin (D,C, and E) used as indicators for chronic periodontitis among DMT2 patients.
Subjects and methods: We enrolled 41 type 2 diabetic patients with chronic periodontitis -18 males and 23
females, aged 60± 14 years and 49 controls- 26 males and 23 females, aged 61.8 ± 12.5 years. Blood samples
were collected after an overnight fast and routine biochemical parameters such as glucose, lipocalin-2 and
visfatin, and vitamin (D,C, and E)were determined in all samples. Data were considered significant at a level
of p < 0.05.Periodontitis status was established using classic clinical parameters, Plaque index (PI), gingival
index (GI), probing depth (PD) and clinical attachment level (CAL). Results: 1) The mean serum of blood
glucose, Visfatin, and LCN2 were higher in patients group than in those with normal control group (P<0.001
for all comparisons) ; 2) patients with had a lower Vitamin D,C, and E than those with a normal group (P <
0.001 for all comparisons).Conclusions: The activity of lipocalin-2 and visfatin in saliva and serum can be
useful in diagnosis, monitorization and treatment of this disease. Further studies are needed to elucidate the
role of lipocalin-2 and visfatin in periodontitis and systemic disease interactions.