Immunoinformatics Analysis of SARS-CoV-2 Isolated from Karst of Bats in Malang, Indonesia

Abstract

In December 2019, cases of mysterious pneumonia were first reported in Wuhan, Initially, the disease
was temporarily named as 2019 novel coronavirus (2019-nCoV), then WHO announced a new name on
February 11, 2020, namely Coronavirus Disease (COVID-19) which is caused by a virus Severe Acute
Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This virus can be transmitted from person to
person and has spread widely in China and more than 190 other countries and territories. Meanwhile in
Indonesia, up to September 2020, 203 thousand cases of COVID-19 were found and 8336 deaths. Bats
act as important disease reservoirs for various etiologic agents of disease that can be transmitted between
species, infecting humans and mammals, both domestic and wild. The purpose of this study was to analyze
SARS-CoV-2 immunoinformatics in bats in Karst Malang Indonesia as the basis for making SARS-CoV-2
vaccines. This research method is SARS-CoV-2 amino acid bats in Karst Malang, Indonesia analyzed by
immunoinformatics. From the research results, it was found that SARS-CoV-2 protein from Malang Karst
bats were antigen, non-allergen and non-toxin, so that they could be used as vaccine candidates, diagnostic
kits and immunotherapy.