Pharmacokinetic Parameters of Meropenem in the Plasma and Milk of Ewes

Abstract

This study had been designed to evaluate the pharmacokinetic parameters of Meropenem in plasma and
milk of ewes after intravenous bolus adminsteration, for this purpose, five healthy miking ewes had been
received a single intravenous bolus of Meropenem (20 mg/kg) to characterize both of distribution and
elimination of Meropenem in plasma and milk, concentrations of Meropenem in plasma and milk had
been analyzed by microbiological method and pharmacokinetic data had been analyzed by compartmental
and noncompartmental methods, results of mean ± standard deviation for half-life, volume of distribution
and total body clearance for plasma samples were 0.67 ± 0.09 h., 0.169 ± 0.01 and 0.3 ± 0.02 L/hr/kg,
respectively, the plasma protein binding ratio were 7.27 ± 0.22 %; while the half-life, Cmax and drug
penetration ratio for milk samples were 9.56 ± 3.13 h, 3.91 ± 0.99 ?g/ml and 0.86 ± 0.23 respectively. In
our conclusions; Depending on the approval state of Meropenem for veterinary therapy, we think that the
achieved pharmacokinetic parameters of Meropenem in plasma and milk of ewes will candidate it to be one
of the preferred parentrally administered antibacterial agents to encounter the acute cases of mastitis that
ought to be treated hastily.