Possible Effect of vitamin D3 on Follicular Maturation in Polycyctic Ovarian Syndrome (PCOS) Women

Abstract

Polycystic ovarian syndrome (PCOS) is the most common reproductive age endocrine condition in women.
Most likely, one of the major problems of PCOS patients are vitamin D3 deficiency. Therefore, investigation
of the association between vitamin D3 deficiency and ovulation in PCOS women patients might help to
explore the possible relationship between them. Sixty-six patients were recruited from a private clinic in
Karbala city / Al-Hindiya district, Iraq. The patients were divided into two groups (33 patients each), the
first group treated with metformin 850 mg, b.i.d, and placebo. The second group treated with metformin 850
mg, b.i.d and vitamin D3 oral supplementation 5000 IU/day for 3 months. Ultrasonography was performed
monthly on day 13 to assess the follicular size. D3 blood level was measured at the end of the 3 months.
The present study demonstrated that daily D3 5000IU in PCOS women with deficient D3 whom already on
scheduled metformin 850 mg b.i.d for 3 months significantly (p<0.05) increased the mid-cycle follicular
size by one 3rd in comparison to placebo group. The important finding was that vitamin D3 might enhance
follicular maturation in PCOS patients.