Profile Quantitative Hepatitis B Surface Antigen (qHBsAg) of Chronic Nai?ve Hepatitis B Patients in Dr. Soetomo Hospital, Surabaya, Indonesia

Abstract

This study aimed to evaluate the profile of qHBs Ag profile, and also to investigate the correlation between
qHBs Ag and HBV DNA. Seventy samples of chronic-nai?ve hepatitis B patients in Dr. Soetomo Hospital
were analyzed in a cross-sectional study. Patients were categorized according to the HBe Ag positive (n=30)
and HBe Ag negative (n=18), also based on qHBs Ag 1000 IU/mL and qHBs Ag >1000 IU/mL. qHBs Ag
was correlated with HBV DNA. qHBs Ag by CLEIA method from Sysmex, KOBE HISCL, HBV DNA
was measured by real-time Polymerase Chain method from Gene Xpert, Cepheid. 70 patients nai?ve CHB
treatment showed a median of ALT level 60.21±70.76 U/L. 30 patients showed a positive-HBeAg, 18 patients
showed negative-HBeAg, 22 patients were not evaluated (N/A). Positive-HBeAg patients had 70% qHBsAg
>2500 mg/dL and median HBV DNA 7.49×107
IU/mL. Negative-HBeAg patients had 55.6% HBsAg ?1000
mg/dL and median HBV DNA 9.66×102 IU/mL. qHBsAg correlated with HBV DNA (p <0.001). This data
demonstrated that quantitative HBsAg was associated with a phase of HBV-infection, quantitative HBsAg
showed a moderate correlation with DNA HBV, quantitative HBsAg levels might be a predictor of initiation
therapy for CHB patients.