Platelet Rich Fibrin( PRF )-A Novel Generation of Regeneration in Endodontics: A Review

Abstract

In the field of regenerative medicine, PRP/PRF whichwas will be is used as a surgical adjuvant became
the new glorified approach. For the Regenerative endodontic treatment based on the tissue engineering
concept, creating a favourable environment free of pathogens, for preservation and migration of stem cells,
pathogen eradication, stem cell preservation, presence of scaffold facilitating spatial orientation and signal
molecules released by cells is of utmost importance. In tooth revascularisation and revitalization, successful
application of platelet concentrates as scaffolds have been reported. Being autologous, comprising of high
growth factor concentrates and relatively hassle-free preparation in dental setup, platelet concentrates are
preferred. The advancement in the regenerative endodontics field, with the introduction of the different
generation of platelet concentrates, is a breakthrough.