Involvement of Insulin Like Growth Factor-I Gene Polymorphism with Diabetes and Diabetic Nephropathy in Individuals with Type 2 Diabetes in Babylon Province

Abstract

Concerning type 2 diabetes mellitus (T2DM), diabetic nephropathy (DN) is a chiefmicrovascular complication.
Preceding studies have proposed that insulin-like growth factor-1(IGF-1) signaling might do a significant
role in DN. The existing study was implemented to explorethe allianceof single nucleotide polymorphism
(SNP) rs6214 of the IGF-1gene with T2DM and DN. The study consists of three groups, the first oneincludes
50 subjects, those were apparently healthy were considered as controls. The second oneinvolves 69 patients
with T2DM without nephropathy and the third oneencompasses 89 patients who suffer from T2DM with
DN. The analysis of results elucidated that thegenotype CT was decided to significantly increase the hazard
of T2DM by about 2 folds and the genotype TT was established to significantly increase the risk of DN by
about 3 folds with respect to those of the genotype CC. This study concludes that theSNPrs6214 of theIGF-1
gene associated with T2DM and DN.