Synthesis, Characterization, Molecular Docking of Sulphamethoxazole Schiff Base Metal Complexes and Its Antibacterial, Anti-Inflammatory and Anti Depressant Activity

Authors

  • R.Gandhimathi
  • Magdivari Sangeetha

DOI:

https://doi.org/10.37506/ijfmt.v16i1.17413

Keywords:

Sulphamethoxazole, antibacterial, anti-inflammatory, antidepressant activity

Abstract

In our study we have a tendency to synthesized schiff’ base of bactericide drug sulphamethoxazole on
treating with aromatic aldehydes like p-diethyl amino benzyldehyde and p-dimethyl amino benzyldehyde.
The synthesized schiff’s bases were regenerate to its ion Schiff bases by treating with methyl group
halide. The ion Schiff bases were regenerate to metal complexes by treating with metals like CuCl2,
ZnCl2 and CdCl2. All the synthesized compounds were characterised by Elemental analysis, IR and
H proton magnetic resonance. Docking study was performed to know the interaction of binding sites
with protein receptor using MAO-B enzymes (PDB ID: 2BK5) and COX-2 enzyme (PDB ID: 5IKR)
by Virtual Screening software for Computational Drug Discovery. Synthesized metal complexes were
evaluated for antibacterial, anti inflammatory and antidepressant activity. Copper metal complexes
showed potent antibacterial and anti-inflammatory activity. Significant anti-depressant activity was
shown for 2A2 and 2B2 zinc metal complexes

Author Biographies

  • R.Gandhimathi

    Professor Department of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, 

  • Magdivari Sangeetha

    Research Scholar  Department of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu,

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Published

2021-11-02

How to Cite

Synthesis, Characterization, Molecular Docking of Sulphamethoxazole Schiff Base Metal Complexes and Its Antibacterial, Anti-Inflammatory and Anti Depressant Activity. (2021). Indian Journal of Forensic Medicine & Toxicology, 16(1), 47-57. https://doi.org/10.37506/ijfmt.v16i1.17413