Serum Preptin Level in Iraqi Beta Major Thalassemic Patients

Abstract

Background Beta thalassemia syndromes are a set of hereditary blood disorders marked by a deficiency of beta-globin chain synthesis, result in decrease hemoglobin in red blood cells, anemia, and a reduced RBC production. Iron overload is a common finding in chronically transfused beta thalassemia major patients with possible effect on beta cell function and secretion. This study aimed to assess preptin level in the serum in beta major thalassemic patients, in order to indicate the effect of oxidative stress on preptin secretion. And explain preptin effect on bone cells. Subject and methods; A case-control study that was performed in the Ibn Albaladi Hospital (during the period from 1st of September 2020 to the end of January 2021. It included 48 beta major thalassemic patients and 36 subject as healthy control. Information was taken from each subject including age, diseases. Subjects with any cardiovascular diseases, hyperemesis gravidram, liver diseases, kidney diseases, bone disease, diabetes mellitus, and patients take corticosteroid as well as patients in childhood were excluded in this study. The biomarkers studied were: fasting serum preptin, insulin were assessed. Serum preptin and insulin were measured by ELISA technique. Results; The mean values of (Preptin, Insulin) in patients group were less than control group. There was a moderate direct significant correlation P<0.01 between preptin and insulin. Conclusion; The mean value of serum preptin was less in thalassemic major group than control group. And direct correlated with insulin level which is also reduced in thalassemic patients.