myc Gene and Cancer Variant Analysis and Network Interaction: An In-Silico Analysis

Abstract

The myc is a proto-oncogene that regulates the cellular process like cell growth, proliferation,
metabolism, apoptosis and malignancy pathologies. myc deregulation occurs in several cancers and
plays a significant role in disease development, metastatic potential, and therapeutic resistance. Drug
targeting myc in cancer remains highly desirable with substantial challenges, delaying the direct myc
targeted drugs’s development. These drugs target the myc transcriptions deregulations in tumours cell
by compound inhibiting the inducing of epigenetic silencing or regulation of G-quadruplex structures
within the myc promoter. Proteins involved in myc’s post-translational modulation have been identified
as significant surrogate targets for lowering myc activity downstream of aberrant cell stimulatory
signals.