Prostate Specific Antigen as Predictive Factor for Androgenemia in Women

Abstract

Background: Sex hormones of steroid origin - androgens, play an important role in the life of the
body. They are involved in the regulation of bone maturation, gonadotropin secretion and the synthesis
of high-density lipids, the production of β-endorphins. Along with the anabolic effect, androgens
regulate libido and sexual potency, stimulate the function of the sebaceous glands and hair follicles.
At physiological concentrations, androgens participate in the regression mechanism of the follicle in
the ovaries and provide pubic hair and inguinal hair growth .The present study was conducted with
the aim the possibility of using PSA for the diagnosis of hyper androgenic conditions in women. The
study included 105 girls aged 17–26 were examined. The concentration in the peripheral blood of
PSA and a androgens, testosterone and DHEA-S, were determined. In addition, the concentration of
the transport proteins of androgens SHBG and albumin was investigated. The calculation of (FT) and
(BT) was carried out according to special computer programs. The aim of this work was diagnostics of
hyperandrogenic conditions in women. The result shows that the concentration of PSA increases with
an increase in T peripheral blood, the concentration of PSA increases with an increase in DHEA-S in
peripheral blood and the concentration of PSA increases with an decrease in SHBG in peripheral blood.
In conclusion, we found that there is a relationship between androgen levels and PSA concentration in
peripheral blood, and PSA is a valuable marker in the diagnosis of hyperandrogenism in women.