The Possible Effect of Celastrol on Ameliorating Mitochondrial Dysfunction and Neuro-inflammation in Sodium Valproate Induced- Rat Model of Autism
DOI:
https://doi.org/10.37506/ijfmt.v16i2.17920Keywords:
ASD, celastrol and mitochondrial dysfunction.Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disease with impairment in social interactions,
language and repetitive stereotypical behaviors. Celastrol is a natural safe compound that has antiinflammatory
and as a neuroprotective effects. 48 male offspringswistar rats divided into 6 groups;
normal control group, offsprings receive vehicle, autistic offsprings receive vehicle, autistic offsprings
receive risperidone, autistic offspringsreceive celastrol, autistic offspringsreceive both risperidone&
celastrol. At the end of experiment behavioral tests were performed then neurochemical analysis
and histopathological examination. The obtained data showed that celastrol improved social deficits,
decreased repetitive/restricted behaviors in T-maze test, significant increase in SIRT-1, GSH level
with significant decrease in DRP-1, IL-6, caspase-3 and MDA with amelioration of histopathological
findings in VPA-induced ASD in both cerebellum and hippocampus. These findings pave the way for
using celastrol as an adjuvant therapy during long-term clinical use of risperidone in ASD.
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Copyright (c) 2022 AmlAlaa El-Din El-Sayed Ahmed, Samia HussienAbou El-Seoud, Fleur Fathi Abdel Moneim, Rasha Osama El-Esawy

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