The Possible Effect of Celastrol on Ameliorating Mitochondrial Dysfunction and Neuro-inflammation in Sodium Valproate Induced- Rat Model of Autism

Authors

  • AmlAlaa El-Din El-Sayed Ahmed
  • Samia HussienAbou El-Seoud
  • Fleur Fathi Abdel Moneim
  • Rasha Osama El-Esawy

DOI:

https://doi.org/10.37506/ijfmt.v16i2.17920

Keywords:

ASD, celastrol and mitochondrial dysfunction.

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disease with impairment in social interactions,
language and repetitive stereotypical behaviors. Celastrol is a natural safe compound that has antiinflammatory
and as a neuroprotective effects. 48 male offspringswistar rats divided into 6 groups;
normal control group, offsprings receive vehicle, autistic offsprings receive vehicle, autistic offsprings
receive risperidone, autistic offspringsreceive celastrol, autistic offspringsreceive both risperidone&
celastrol. At the end of experiment behavioral tests were performed then neurochemical analysis
and histopathological examination. The obtained data showed that celastrol improved social deficits,
decreased repetitive/restricted behaviors in T-maze test, significant increase in SIRT-1, GSH level
with significant decrease in DRP-1, IL-6, caspase-3 and MDA with amelioration of histopathological
findings in VPA-induced ASD in both cerebellum and hippocampus. These findings pave the way for
using celastrol as an adjuvant therapy during long-term clinical use of risperidone in ASD.

Author Biographies

  • AmlAlaa El-Din El-Sayed Ahmed

    Demonstrator of Pharmacology,Faculty of Medicine, Tanta University, Egypt

  • Samia HussienAbou El-Seoud

    Professor of Pharmacology, Faculty of Medicine, Tanta University, Egypt

  • Fleur Fathi Abdel Moneim

    Professor of Pharmacology, Faculty of Medicine, Tanta University, Egypt

  • Rasha Osama El-Esawy

    Lecturer of Pharmacology, Faculty of Medicine, Tanta University, Egypt

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Published

2022-04-12

How to Cite

The Possible Effect of Celastrol on Ameliorating Mitochondrial Dysfunction and Neuro-inflammation in Sodium Valproate Induced- Rat Model of Autism. (2022). Indian Journal of Forensic Medicine & Toxicology, 16(2), 65-76. https://doi.org/10.37506/ijfmt.v16i2.17920