The Relation between the Plasma Level of Testosterone Hormone and the Severity of COVID-19 in Iraqi Patients
DOI:
https://doi.org/10.37506/ijfmt.v16i2.17983Keywords:
COVID-19 ,Testosterone level, Severity.Abstract
Coronavirus disease 2019 discovered in December 2019, Wuhan, China. It was transmitted globally
producing the present COVID-19 pandemic. Concerns have been raised about the potential impact
of COVID-19 on male reproductive organs and male fertility as the number of infections in the male
community has increased. The objectives of current study are studying the relationship between the
plasma levels of testosterone and the markers of immune reaction with the severity and mortality in
a sample of COVID-19 patients. A cross section study included NO= 103 male patients affected by
SARS- CoV-2 pneumonia, diagnosed by PCR and chest CT scan, (≥ 18 years old), and recovered
in the respiratory intensive care unit (RICU). Several biochemical risk factors were determined Free
Testosterone, sex hormone binding globulin (SHBG) were measured by Enzyme-Linked Immunosorbent
Assay(ELISA), D-dimer, Ferritin, CRP, Urea, Creatinine were measured by automated method by
using Abbott Architect c4000 and Complete Blood Count(CBC). The results show that the serum free
testosterone and SHBG levels a significant lower in non-survivor patients than survivor patients with
COVID-19. While the other biomarkers (D-dimer, Ferritin, Urea, Creatinine) were significant higher in
non-survivor patients than survivor patients. The CRP, WBC and lymphocyte showed that no significant
between the both group of patients. In conclusion the study showed that lower free testosterone and
SHBG levels enable significant role in increasing risk of COVID-19 mortality amongst adult male
patients
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