Comparison of Akt Expression in the Cerebrum and Cerebellum of Newborn Mus musculus Exposed to Physical Stress and Psychological Stress During Pregnancy

Abstract

Introduction: Prenatal stress prevalence is almost half of the population of pregnant women worldwide.
Stress will stimulate glucocorticoids which can disrupt the PI3K-Akt cascade. PI3K-Akt deficiency will
cause impaired fetal brain growth and development.
Objective: To compare the Akt expression in the cerebrum and cerebellum of newborn Mus musculus
exposed to physical stress, psychological stress, the combination of psychological and physical stress, and
without stress exposure.

Method: This study was experimental laboratory research. Twenty-four female mice were used as samples
and divided into four groups: physical stress exposure group, psychological stress exposure group, the
combination of psychological and physical stress exposure group, and control group. Akt expression was
tested by immunohistochemistry (IHC) staining. Statistical analysis used the One Way Anova and Kruskal
Wallis test.