The Development and Standardization of a Proctological Agent Based on Black Cumin (Nigella Sativa L.) Extract
DOI:
https://doi.org/10.37506/ijfmt.v16i4.18610Keywords:
: dry extract of Nigella sativa, suppositories, thymoquinone, anti-inflammatory activityAbstract
Annotation. Nigella sativa L. (Ranunculaceae) is one of the promising plants that has a wide spectrum of
pharmacological activity. The black cumin is known to have been used for the treatment of cataracts, bronchial
asthma, cholelithiasis and urolithiasis, helminthic invasions, diabetes, hemorrhoids, and many other diseases.
The aim of this study is to develop and standardize a drug based on a dry extract of the black seed– black cumin
(Nigella sativa L.).
The technology of preparing suppositories of N. sativa dry extract by fusion molding was proposed, and its
antiulcer activity was studied. The quality of suppositories was assessed according to the following indicators:
characteristics, average weight of suppositories, melting point, identification, quantification. The study of the
antiulcer activity of the drug was carried out on the model of phenolic proctitis. It was found that the tested drug
significantly reduces the area of necrosis, hyperemia, and also significantly reduces the edema and the length of
the damaged section of the intestine relative to the entire length of the rectum, on the model of phenolic proctitis.
The data obtained indicate the presence of reliable antiulcer activity in the tested drug, which gives reason to
recommend it for proctitis, hemorrhoids and in a number of other proctological diseases with concomitant
inflammation, edema, hyperemia and ulceration.
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