Nephrotoxicity Related to Iodinated-Based Contrast Media: From Pathophysiology to Management

Authors

  • Oktavinayu Sari Latif
  • Tenta Hartian Hendyatama

DOI:

https://doi.org/10.37506/ijfmt.v16i4.18613

Keywords:

s: Iodinated Contrast Media, Contrast Induced Acute Kidney Injury, Nephrotoxicity

Abstract

Contrast Induced Nephropathy (CIN) or Contrast Induced Acute Kidney Injury (CI-AKI) is defined as sudden
deterioration of renal function which is caused by administration of contrast media. Iodinated Contrast Media
(ICM) is frequently used to enhance anatomical structure in medical imaging, for both diagnostic and therapeutic
procedure, such as angiography, urography, and coronary intervention. The pathophysiology of nephrotoxicity
related to ICM has not been completely understood. Hemodynamic changes, direct tubular cell toxicity and
oxidative stress may contribute to pathophysiology of CI-AKI. Screening patient’s risk factors, selecting contrast
and avoiding nephrotoxic drug are several ways to be performed prior to administration of ICM to avoid CI-AKI.
In addition to fluid administration and hemodialysis, medications such as N-acetylcysteine, statins, furosemide
and nebivolol can be used to manage CI-AKI

Author Biographies

  • Oktavinayu Sari Latif

    Doctor at Emergency Department, Lawang Medika Hospital, Malang, East Java, Indonesia,

  • Tenta Hartian Hendyatama

    Internist at Internal Medicine Department, Djatiroto Hospital, Lumajang, East Java, Indonesia

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Published

2022-10-10

How to Cite

Nephrotoxicity Related to Iodinated-Based Contrast Media: From Pathophysiology to Management. (2022). Indian Journal of Forensic Medicine & Toxicology, 16(4), 349-356. https://doi.org/10.37506/ijfmt.v16i4.18613