Nephrotoxicity Related to Iodinated-Based Contrast Media: From Pathophysiology to Management
DOI:
https://doi.org/10.37506/ijfmt.v16i4.18613Keywords:
s: Iodinated Contrast Media, Contrast Induced Acute Kidney Injury, NephrotoxicityAbstract
Contrast Induced Nephropathy (CIN) or Contrast Induced Acute Kidney Injury (CI-AKI) is defined as sudden
deterioration of renal function which is caused by administration of contrast media. Iodinated Contrast Media
(ICM) is frequently used to enhance anatomical structure in medical imaging, for both diagnostic and therapeutic
procedure, such as angiography, urography, and coronary intervention. The pathophysiology of nephrotoxicity
related to ICM has not been completely understood. Hemodynamic changes, direct tubular cell toxicity and
oxidative stress may contribute to pathophysiology of CI-AKI. Screening patient’s risk factors, selecting contrast
and avoiding nephrotoxic drug are several ways to be performed prior to administration of ICM to avoid CI-AKI.
In addition to fluid administration and hemodialysis, medications such as N-acetylcysteine, statins, furosemide
and nebivolol can be used to manage CI-AKI
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