Moringa oleifera Ameliorates Chlorpyrifos Induced Oxidative Stress in Male Wistar Rats

Authors

  • Onimisi B.O
  • Zagga A.D
  • Okolo R.U
  • Abubakar M.S
  • Usman Z
  • Akor J
  • Idris S.B

DOI:

https://doi.org/10.37506/ijfmt.v16i4.18615

Keywords:

chlopyrifos, oxidative stress, Moringa oleifera, relative organ weight.

Abstract

Background: Chlorpyrifos is a widely used organophosphate pesticide. It exerts its toxic effect by inhibiting of
cholinesterases and induction of oxidative stress.
Methods: In the present study,Soya oil, Chlopyrifos,Moringa oleifera, Chlopyrifos + Moringa oleifera, were given to
male rats through gavage for 2 weeks.The influence of chlorpyrifos on brain cholinesterase activity and indicators
of oxidative stress malondialdehydecatalase, glutathione, superoxide dismutaseand also histopathological
changes in the brain of Wistar rats was investigated compared to control group.
Results: There was significant increase in the brain malondialdehyde of the chlopyrifos group compared to the
control and chlopyrifos+Moringa oleifera group. Also there were significant decreases in the superoxide dismutase,
catalase, glutathione and acetylcholinesterase concentrations in the chlopyrifosgroup compared to the control and
chlopyrifos + Moringa oleifera group. The rats showed significant changes in body, liver, kidneys and heart weights
No significant haematological changes were seen following treatment. While some histopathological changes
were detected in brain tissues in the chlopyrifos treated group, less histopathological changes were observed in
chlopyrifos +Moringa oleifera treated groups at the end of the 2 weeks’ study.
Conclusion: Overall, these results support the hypothesis that chlopyrifos causes oxidative stress and Moringa
oleiferaextract can help reduce the changes induced by chlopyrifos.

Author Biographies

  • Onimisi B.O

    Lecturer, Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences,
    Usmanu Danfodiyo University, Sokoto,

  • Zagga A.D

     Professor, Department of Anatomy, Faculty of BasicMedical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto

  • Okolo R.U

    Associate Professor, Department of Human Anatomy, Faculty of Basic Medical Sciences, College of
    Health Sciences, University of Abuja,

  • Abubakar M.S

    Professor, Department of Veterinary Pathology Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto

  • Usman Z

    Lecturer, Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences,
    Usmanu Danfodiyo University, Sokoto

  • Akor J

    Federal Medical Centre,BirninKebbi, Kebbi state, 

  • Idris S.B

    Lecturer, Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto.

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Published

2022-10-10

How to Cite

Moringa oleifera Ameliorates Chlorpyrifos Induced Oxidative Stress in Male Wistar Rats. (2022). Indian Journal of Forensic Medicine & Toxicology, 16(4), 357-363. https://doi.org/10.37506/ijfmt.v16i4.18615