Moringa oleifera Ameliorates Chlorpyrifos Induced Oxidative Stress in Male Wistar Rats
DOI:
https://doi.org/10.37506/ijfmt.v16i4.18615Keywords:
chlopyrifos, oxidative stress, Moringa oleifera, relative organ weight.Abstract
Background: Chlorpyrifos is a widely used organophosphate pesticide. It exerts its toxic effect by inhibiting of
cholinesterases and induction of oxidative stress.
Methods: In the present study,Soya oil, Chlopyrifos,Moringa oleifera, Chlopyrifos + Moringa oleifera, were given to
male rats through gavage for 2 weeks.The influence of chlorpyrifos on brain cholinesterase activity and indicators
of oxidative stress malondialdehydecatalase, glutathione, superoxide dismutaseand also histopathological
changes in the brain of Wistar rats was investigated compared to control group.
Results: There was significant increase in the brain malondialdehyde of the chlopyrifos group compared to the
control and chlopyrifos+Moringa oleifera group. Also there were significant decreases in the superoxide dismutase,
catalase, glutathione and acetylcholinesterase concentrations in the chlopyrifosgroup compared to the control and
chlopyrifos + Moringa oleifera group. The rats showed significant changes in body, liver, kidneys and heart weights
No significant haematological changes were seen following treatment. While some histopathological changes
were detected in brain tissues in the chlopyrifos treated group, less histopathological changes were observed in
chlopyrifos +Moringa oleifera treated groups at the end of the 2 weeks’ study.
Conclusion: Overall, these results support the hypothesis that chlopyrifos causes oxidative stress and Moringa
oleiferaextract can help reduce the changes induced by chlopyrifos.
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