A Rare Complication of Intravenous Phenytoin Induced Purple Glove Syndrome

Authors

  • Tamilselvan
  • Lakshmi sabapathi
  • Syedraja
  • Karthikeyan
  • Gunaseelan
  • Mayakrishnan
  • Veenu

DOI:

https://doi.org/10.37506/ijfmt.v17i4.19968

Keywords:

Generalised tonic-clonic seizure, Phenytoin, Complication, Purple glove syndrome

Abstract

Purple Glove Syndrome is a relatively uncommon complication of intravenous phenytoin administration with
clinical manifestations of pain, edema, and purple-blue discoloration at the injection site. Here we report a case
of Purple Glove syndrome induced by intravenous administration of phenytoin. The case report describes about a
75-year-old male, who presented to the Emergency Department with chief complaints of generalized tonic - clonic
seizures for which he was managed with Inj. Phenytoin. Later patient sensorium improved and 4 hours later the
patient had pain and swelling over the left hand and wrist distal to the IV cannula site followed by reddish-purple
discoloration over the edematous site. Left upper limb Doppler was done & it showed left-hand cellulitis with no
evidence of thrombus. Then the patient was reassured and treated with removal of IV cannula, left-hand elevation,
warmth application, analgesics and change of antiepileptics. Such medications like phenytoin should be handled
carefully to avoid difficulties in the future. Early detection, rapid monitoring, and management are essential.

Author Biographies

  • Tamilselvan

    Assistant Professor, Department of General Medicine, Government Medical College and Hospital,
    Nagapattinam, Tamilnadu, India

  • Lakshmi sabapathi

    Assistant Professor, Department of Pharmacy Practice, E.G.S Pillay college of Pharmacy, Nagapattinam,

  • Syedraja

    Internship, E.G.S Pillay college of Pharmacy, Nagapattinam, Tamilnadu, India,

  • Karthikeyan

    Internship, E.G.S Pillay college of Pharmacy,Nagapattinam, Tamilnadu, India

  • Gunaseelan

    Internship, E.G.S Pillay college of Pharmacy, Nagapattinam, Tamilnadu, India

  • Mayakrishnan

    Internship, E.G.S Pillay college of Pharmacy,Nagapattinam, Tamilnadu, India,

  • Veenu

    Internship, E.G.S Pillay college of Pharmacy,Nagapattinam, Tamilnadu, India,

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Published

2023-10-16

How to Cite

A Rare Complication of Intravenous Phenytoin Induced Purple Glove Syndrome. (2023). Indian Journal of Forensic Medicine & Toxicology, 17(4), 151-154. https://doi.org/10.37506/ijfmt.v17i4.19968