Comparison of SOFA and APACHE II in Predicting Mortality, Morbidity in Cases of Acute Poisoning and Correlation with Biomarkers of Severity
DOI:
https://doi.org/10.37506/2t2s8g25Keywords:
Mortality and morbidity, SOFA, APACHE II, Acute poisoningAbstract
Introduction
The aim of this research is to compare SOFA and APACHE II scores for the ability to predict mortality and morbidity among patients of acute poisoning. The secondary aim is to relate these scores with biomarkers of severity to determine their prognostic value. Acute poisoning is one of the most important health problem across the globe, a major contributor to the emergency admissions leading to increased morbidity and mortality. Prognosticating measures like SOFA and APACHE II are essential in prioritizing the patients and planning their management. This study assesses their relative roles in predicting the outcome in patients with acute poisoning presenting to the emergency of a tertiary care hospital in Northern India.
Materials & Methods
This was a prospective observational study conducted at Government Medical College and Hospital Chandigarh , where 85 patients who had acute poisoning were recruited. The severity score tools were applied and they were compared with the severity markers. The performance of the scores was assessed and the sensitivity and the specificity were analyzed using Receiver Operating Characteristic (ROC) curve analysis.
Results
The SOFA score has been proven to best APACHE II in terms of predictive accuracy. Both scoring systems were found to correlate significantly with NLR, Serum Amylase, and Lactate, with SOFA exhibiting greater sensitivity and specificity.
Conclusion
SOFA serves better in predicting mortality amongst cases of acute poisoning than APACHE II. Strong correlations with critical biomarkers further reinforce the clinical significance of SOFA score.
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Copyright (c) 2025 Ranganath Honnal, Nidhi Bhardwaj, Monica Gupta, Pritam Singh
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