A Retrospective Study on the Impact of Early Hemoperfusion on Survival Outcomes in Acute Paraquat Poisoning
DOI:
https://doi.org/10.37506/akkh2t49Keywords:
Paraquat, Hemoperfusion , Retrospective study, Acute kidney injury, Mechanical ventilationAbstract
Background: Paraquat (PQ) (1,1'-dimethyl-4,4'-bipyridinium dichloride) poisoning is a major global health issue, especially in developing countries. PQ accumulates in pneumocytes, causing cellular damage through reactive oxygen species and leading to pulmonary fibrosis. Despite medical advances, severe cases have a mortality rate exceeding 80%.
Methods: This retrospective observational study analyzed 30 patients over six months in the Emergency Medicine Department (ED) of a tertiary hospital in India. Adults (≥18 years) with confirmed paraquat poisoning, via history or positive urine dithionite test, admitted between January 2024 and June 202,4 were included after obtaining ethical committee approval. Cases were identified using ICD-10 code T60.3 and ED records. Data collected included demographics, poisoning details (e.g., time, quantity, time of presentation to ED) and clinical features like respiratory distress, altered mental status, and organ dysfunction. patients who received early hemoperfusion(within 4 hours) of paraquat ingestion had a significantly higher survival rate compared to those who received it later.
Conclusion: The timing of HP administration appears to be associated with 30-day mortality, as indicated by the significant p-value (0.045), suggesting a potential relationship between delayed HP and higher mortality rates.
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Copyright (c) 2025 Kishore Raja, Varun Byrappa, Arun A Mohanan, Shreyas Satish, Anup Kumar Roy
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