Salivary AST Enzyme Level as a Biomarker for Tracking the Progress of Gum Disease Treatment in Children
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Abstract
Background: Periodontal disease is a persistent inflammatory illness characterized by the destruction of supporting components, which may ultimately result in tooth loss. The most often seen kind of periodontal disease in children and adolescents is gingivitis, which has a significant correlation with certain socioeconomic variables and oral health practices. Numerous salivary biomarkers, such as AST, have been suggested as potential indicators for the timely identification and advancement of periodontal disease.
Aims of the study: The aim is to demonstrate the impact of non-surgical periodontal therapy on children with periodontal disease (PD) and determine whether the AST marker may be used to forecast the advancement of gingival illnesses at various stages in pediatric patients.
Materials and Methods: This case-control research included the observation of a cohort of 30 children, with ages ranging from 6 to 12 years. The individuals were categorized into two cohorts according to their periodontal well-being: a cohort of 17 children diagnosed with gingivitis and another cohort of 13 children diagnosed with chronic periodontitis. All participants salivary AST enzyme levels, LI, GI, and CAL were assessed at two time points: baseline and one month follow-up.
Conclusion: Children with gingivitis and chronic periodontitis may benefit from non-surgical periodontal therapy and dental hygiene instruction. Tracking therapy progress in children with periodontal disease may be facilitated by monitoring salivary AST enzyme levels. The measurement of salivary AST enzyme levels provides a non-invasive method for evaluating the effectiveness of therapy in the field of pediatric dental care.
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Muhammad Ashraf Nazir. Prevalence of periodontal disease, its association with systemic diseases and prevention. 2017 p. 72–80.
Albandar JM, Susin C, Hughes FJ. Manifestations of systemic diseases and conditions that affect the periodontal attachment apparatus: Case definitions and diagnostic considerations. J Periodontol. 2018 Jun 21;89(S1).
Lim G, Janu U, Chiou LL, Gandhi KK, Palomo L, John V. Periodontal Health and Systemic Conditions. Dent J (Basel). 2020 Nov 19;8(4):130.
Isola G, Santonocito S, Lupi SM, Polizzi A, Sclafani R, Patini R, et al. Periodontal Health and Disease in the Context of Systemic Diseases. Mediators Inflamm. 2023 May 13;2023:1–19.
Mira A, Simon‐Soro A, Curtis MA. Role of microbial communities in the pathogenesis of periodontal diseases and caries. J Clin Periodontol. 2017 Mar 6;44(S18).
Amano A, Chen C, Honma K, Li C, Settem RP, Sharma A. Genetic Characteristics and Pathogenic Mechanisms of Periodontal Pathogens. Adv Dent Res. 2014 May 15;26(1):15–22.
Luis Muñoz-Carrillo J, Elizabeth Hernández-Reyes V, Eduardo García-Huerta O, Chávez-Ruvalcaba F, Isabel Chávez-Ruvalcaba M, Mariana Chávez-Ruvalcaba K, et al. Pathogenesis of Periodontal Disease. In: Periodontal Disease - Diagnostic and Adjunctive Non-surgical Considerations. IntechOpen; 2020.
Könönen E, Müller H. Microbiology of aggressive periodontitis. Periodontol 2000. 2014 Jun 17;65(1):46–78.
Al-Ghutaimel H, Riba H, Al-Kahtani S, Al-Duhaimi S. Common Periodontal Diseases of Children and Adolescents. Int J Dent. 2014;2014:1–7.
Syed Khaja Aliuddin. Difference between primary and permanent teeth, Sequence of eruption, mixed dentition, causes of tooth loss,. 2021. 22–34 p.
Goran Koch (Editor) SP (Editor), IE (Editor), DH (Editor). Pediatric Dentistry: A Clinical Approach, 3rd Edition. 3rd ed. 2017.
Rathnayake N, Gieselmann DR, Heikkinen A, Tervahartiala T, Sorsa T. Salivary Diagnostics—Point-of-Care diagnostics of MMP-8 in dentistry and medicine. Diagnostics. 2017 Jan 20;7(1):7.
Carolina DN, Rusyanti Y, Susanto A. Comparison of salivary alpha-amylase levels in gingivitis and periodontitis. Dental Journal (Majalah Kedokteran Gigi). 2017 Dec 30;50(4):216.
Korte DL, Kinney J. Personalized medicine: an update of salivary biomarkers for periodontal diseases. Periodontol 2000. 2016 Feb 10;70(1):26–37.
Schmalz G, Li S, Burkhardt R, Rinke S, Krause F, Haak R, et al. MicroRNAs as Salivary Markers for Periodontal Diseases: A New Diagnostic Approach? Biomed Res Int. 2016;2016:1–14.
Dabra S, China K, Kaushik A. Salivary enzymes as diagnostic markers for detection of gingival/periodontal disease and their correlation with the severity of the disease. J Indian Soc Periodontol. 2012;16(3):358.
Tatjana Todorovic 1 ID 1, MVB 2, BL 3, JP 4, MM 4, MK. Salivary enzymes and periodontal disease. 2006 p. 115–9.
MOJGAN PAKNJAD* AR. SALIVARY BIOCHEMICAL MARKERS OF PERIODONTITIS. 2014.
Löe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol. 1967 Nov;38(6):610–6.
Papapanou PN, Kornman KS. Periodontitis Classification. The Journal of the American Dental Association. 2020 Mar;151(3):159.
World Medical Association Declaration of Helsinki. JAMA. 2013 Nov 27;310(20):2191.Shi F, Liu W, Yao Y, Zhang Q, Chen Z, Xian Y, et al. Predictive salivary biomarkers for early diagnosis of periodontal diseases – current and future developments. Turkish Journal of Biochemistry. 2023 Aug
;48(4):335–44.
Patil P, Patil B. Saliva: A diagnostic biomarker of periodontal diseases. J Indian Soc Periodontol. 2011;15(4):310.
Giannobile W V., Beikler T, Kinney JS, Ramseier CA, Morelli T, Wong DT. Saliva as a diagnostic tool for periodontal disease: current state and future directions. Periodontol 2000. 2009 Jun 8;50(1):52–64.
Galunska BT, Salim AS, Nikolova MN, Angelova ST, Kiselova-Kaneva YD, Peev SV, et al. Gingival status and prophylactic oral hygiene measures modulate salivary amino acids’ profile in children with plaque-induced gingivitis. Turkish Journal of Biochemistry. 2024 Feb 29;49(1):47–55.
Davidovich E, Grender J, Zini A. Factors Associated with Dental Plaque, Gingivitis, and Caries in a Pediatric Population: A Records-Based Cross-Sectional Study. Int J Environ Res Public Health. 2020 Nov 19;17(22):8595.
Varas F, Zillmann G, Muñoz A, Hassi J, Yévenes I, Echeverría S, et al. Periodontal status and treatment needs of children from 6 to 8 years old in the Santiago Metropolitan Region of Chile. Revista Odonto Ciência (Online). 2011;26(1):10–5.
Chile. Ministerio de Salud. Regulation for the prevention of gingival and periodontal diseases. uman Health Division. Department of Odontology. Chilean Health Ministry; 1998.
Soto L TRJGRGUTMBAW. National diagnosis of the 12 years old adolescents’ oral health and evaluation of the complying degree of the oral health sanitary objectives for 2000-2010. Vol. 11. 2007. p. 34–9.
Zarabadipour M, Makhlooghi Sari M, Moghadam A, Kazemi B, Mirzadeh M. Effects of Educational Intervention on Dental Plaque Index in 9-Year-Old Children. Int J Dent. 2022 Oct 25;2022:1–4.
Soldo M, Matijević J, Malčić Ivanišević A, Čuković-Bagić I, Marks L, Nikolov Borić D, et al. Impact of oral hygiene instructions on plaque index in adolescents. Cent Eur J Public Health. 2020 Jun 27;28(2):103–7.
Nelwan SC, Nugraha RA, Endaryanto A, Dewi F, Nuraini P, Tedjosasongko U, et al. Effect of scaling and root planing on level of immunoglobulin E and immunoglobulin G 4 in children with gingivitis and house-dust mite allergy: A pilot randomised controlled trial. Singapore Dent J. 2019 Dec 8;39(01):21–31.
Ozmeric N. Advances in periodontal disease markers. Clinica Chimica Acta. 2004 May;343(1–2):1–16.
Dabra S, China K, Kaushik A. Salivary enzymes as diagnostic markers for detection of gingival/periodontal disease and their correlation with the severity of the disease. J Indian Soc Periodontol. 2012;16(3):358.
Kudva P, Saini N, Kudva H, Saini V. To estimate salivary aspartate aminotransferase levels in chronic gingivitis and chronic periodontitis patients prior to and following non-surgical periodontal therapy: A clinico-biochemical study. J Indian Soc Periodontol. 2014;18(1):53.
Yoshie H, Tai H, Kobayashi T, Oda‐Gou E, Nomura Y, Numabe Y, et al. Salivary Enzyme Levels After Scaling and Interleukin‐1 Genotypes in Japanese Patients With Chronic Periodontitis. J Periodontol. 2007 Mar;78(3):498–503.