Anterior Ameloblastoma, Masquerading a Residual Cyst: A Case Report

Main Article Content

Shamaila Siddiqui
Malu Pooja Radhesham
Vahanwala Sonal P
Singh Shivani
Soni Sakshi
Pooja Prasad

Abstract

Background: Ameloblastoma is a benign odontogenic tumor of epithelial origin that exhibits a locally aggressive
behaviour with a high level of recurrence and multiple factors involved in its molecular pathogenesis. Anterior
ameloblastoma is a rare variant that makes up about 10% of all its varieties, presents unique difficulties
in diagnosis, especially while differentiating it from other lesions in anterior region. Its vivid range of clinical
manifestation further puzzles in clinical diagnosis and can complicate planning of surgeries and thereby affect
the prognosis. We highlight one such case which mimics a residual cyst and thus mandates importance of thorough
diagnostics.
Case Report: This case report presents a rare occurrence of ameloblastoma in anterior mandible of a 60-yearold
patient who reported a swelling in the lower anterior region, which had been present for 5-6 months and
was initially noticed two years ago when it was smaller. This case report aims to highlight the unusual location
of the tumor, the clinical and radiological findings and the treatment modalities employed.
Conclusion: Promptness in diagnosis and relevant treatment of ameloblastoma is crucial due to its malignant
potential and recurrence rate. It underscores the importance of early detection and intervention, which can
significantly improve patient prognosis and reduce the risk of recurrence. Further, it emphasizes the need for
regular follow-ups to monitor any risk of recurrence or any other complications.

Article Details

How to Cite
Anterior Ameloblastoma, Masquerading a Residual Cyst: A Case Report. (2025). Indian Journal of Contemporary Dentistry, 13(1), 7-12. https://doi.org/10.37506/q991kc90
Section
Case Study
Author Biographies

Shamaila Siddiqui, Nair Hospital Dental College

Post-graduate Student, department of Oral Medicine and Radiology, Nair Hospital Dental College

Malu Pooja Radhesham, Government Dental College, Aurangabad

Asisstant Professor department of Oral Medicine and Radiology, Government Dental College, Aurangabad

Vahanwala Sonal P, Nair Hospital Dental College of Oral Medicine and Radiology, Nair Hospital

Associate Professor department Of Oral Medicine and Radiology, Nair Hospital Dental College of Oral Medicine and Radiology, Nair Hospital

Singh Shivani, Nair Hospital Dental College

MDS Department Of Oral Medicine and Radiology, Nair Hospital Dental College

Soni Sakshi, Nair Hospital Dental College

Post-graduate Student, department of Oral Medicine and Radiology, Nair Hospital Dental College

Pooja Prasad, Nair Hospital Dental College

Assisstant Professor Department Of Oral And Maxillofacial Pathology, Nair Hospital Dental College

How to Cite

Anterior Ameloblastoma, Masquerading a Residual Cyst: A Case Report. (2025). Indian Journal of Contemporary Dentistry, 13(1), 7-12. https://doi.org/10.37506/q991kc90

References

Effiom OA, Ogundana OM, Akinshipo AO, Akintoye SO.

Ameloblastoma: current etiopathological concepts

and management. Oral diseases. 2018 Apr;24(3):

-16.

Medina A, Velasco Martinez I, McIntyre B, Chandran R.

Ameloblastoma: clinical presentation, multidisciplinary

management and outcome. Case Reports in Plastic Surgery

and Hand Surgery. 2021 Jan 1;8(1):27-36.

Guan P, Wong SF, Lim JQ, Ng CC, Soong PL, Sim CQ, Ong CK,

Rajasegaran V, Myint SS, Lee JY, Tan HK. Mutational signatures

in mandibular ameloblastoma correlate with smoking.

Journal of Dental Research. 2019 Jun;98(6):652-8.

Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao

L, Lim MS, Elenitoba-Johnson KS, Betz BL. Activating

FGFR2–RAS–BRAF mutations in ameloblastoma. Clinical

Cancer Research. 2014 Nov 1;20(21):5517-26.

Sweeney RT, McClary AC, Myers BR, Biscocho J, Neahring

L, Kwei KA, Qu K, Gong X, Ng T, Jones CD, Varma S. Identification

of recurrent SMO and BRAF mutations in ameloblastomas.

Nature genetics. 2014 Jul;46(7):722-5.

. Heikinheimo K, Kurppa KJ, Elenius K. Novel targets for the

treatment of ameloblastoma [Internet]. Vol. 94, Journal

of Dental Research. SAGE Publications Inc.; 2015 [cited

Jun 30]. p. 237–40.

Titinchi F, Morkel J. Residual cyst of the jaws: A clinico-

pathologic study of this seemingly inconspicuous lesion.

Plos one. 2020 Dec 17;15(12):e0244250.

Kondamari SK, Taneeru S, Guttikonda VR, Masabattula GK.

Ameloblastoma arising in the wall of dentigerous cyst:

Report of a rare entity. Journal of oral and maxillofacial

pathology. 2018 Jan 1;22(Suppl 1):S7-10.

Krishnamurthy V, Haridas S, Garud M, Vahanwala S, Nayak

CD, Pagare SS. Radicular cyst masquerading as a multilocular

radiolucency. Quintessence International. 2013

Jan 1;44(1).

Fuchigami T, Ono Y, Kishida S, Nakamura N. Molecular

biological findings of ameloblastoma. Japanese Dental

Science Review. 2021 Nov 1;57:27-32.

Rayamajhi S, Shrestha S, Shakya S, Bhandari S, Twayana

AR, Shahi K. Unicystic ameloblastoma of mandible: A

case report. JNMA: Journal of the Nepal Medical Association.

Jul;60(251):657.

Ghai S. Ameloblastoma: an updated narrative review of

an enigmatic tumor. Cureus. 2022 Aug;14(8).

Malakar A, Kumar VR, Yadav P, Bhardwaj V, Barua CG,

Bhardwaj G. The Role of BRAF Inhibitors in the Management

of Ameloblastoma: A Literature Review. Cureus.

Oct;15(10).

Nguyen J, Saffari PS, Pollack AS, Vennam S, Gong X, West

RB, Pollack JR. New ameloblastoma cell lines enable preclinical

study of targeted therapies. Journal of Dental Research.

Nov;101(12):1517-25.