Factors Affecting Medication Adherence in Patients with Heart Failure: A Systematic Review

Main Article Content

Abbas Heydari
Zahra sadat Manzari
Atefeh Dehnoalian

Abstract

Background: This research aims to identify the key factors influencing medication adherence among individuals
diagnosed with heart failure
Methods: we searched PUBMED, Web of Science, and Scopus from January 2014 to October 2024 to locate the most recent
original cross-sectional studies that addressed the factors affecting medication adherence in patients with heart failure.
Conclusion: The initial search identified 123 studies, of which we included 15 qualitative studies in the systematic review.
We categorized the factors as patient-specific, disease- and treatment-specific, demographic-related, and psychologicalrelated.
Education level, socioeconomic status, comorbidity, polypharmacy, marital status, depression and anxiety, patientprovider
relationships, self-efficacy, health literacy, and forgetfulness appeared to be the factors affecting medication
adherence in patients with heart failure from the studies.

Article Details

How to Cite
Factors Affecting Medication Adherence in Patients with Heart Failure: A Systematic Review. (2025). International Journal of Nursing Care, 13(2), 1-13. https://doi.org/10.37506/bkvncn58
Section
Review Article
Author Biographies

Abbas Heydari, Mashhad University of Medical Sciences, Mashhad, Iran

Department of Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran

Zahra sadat Manzari, Mashhad University of Medical Sciences, Mashhad, Iran

Department of Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran

Atefeh Dehnoalian, Mashhad University of Medical Sciences, Mashhad, Iran

Student Research Committee, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran

How to Cite

Factors Affecting Medication Adherence in Patients with Heart Failure: A Systematic Review. (2025). International Journal of Nursing Care, 13(2), 1-13. https://doi.org/10.37506/bkvncn58

References

Jarab AS, Al-Qerem WA, Hamam H, Heshmeh SA, Al-Azzam S, Mukattash TL, Alefishat EA. Glycemic control and its associated factors among diabetic heart failure outpatients at two major hospitals in Jordan. PLoS ONE. 2023;18(10 October).10.1371/journal.pone.0285142

Jarrah M, Khader Y, Alkouri O, Al-Bashaireh A, Alhalaiqa F, Al Marzouqi A, et al. Medication adherence and its influencing factors among patients with heart failure: A cross sectional study. Medicina. 2023;59(5):960.https://doi.org/10.3390/medicina59050960

Wu J-R, Moser DK, Lennie TA, Peden AR, Chen Y-C, Heo S. Factors influencing medication adherence in patients with heart failure. Heart & Lung. 2008;37(1):8-16. e1.10.1016/j.hrtlng.2007.02.003

Ruppar TM, Cooper PS, Mehr DR, Delgado JM, Dunbar‐Jacob JM. Medication adherence interventions improve heart failure mortality and readmission rates: systematic review and meta‐analysis of controlled trials. Journal of the American Heart Association. 2016;5(6):e002606.10.1161/JAHA.115.002606.

Control CfD, Prevention. Tailored pharmacy-based interventions to improve medication adherence. 2023.

Silavanich V, Nathisuwan S, Phrommintikul A, Permsuwan U. Relationship of medication adherence and quality of life among heart failure patients. Heart&Lung. 2019;48(2):105-10.https://doi.org/10.1016/j.hrtlng.2018.09.009

Ahmadi L, Haririan H, Hassankhani H. Relationship Between Treatment Adherence and the Risk of Cardiovascular Diseases Among Patients With Coronary Artery Stents. Iran Journal of Nursing. 2023;36(143):256-69.10.32598/ijn.36.143.461.4

Daei MM, Zeighami R, Arjeini Z, Alipour Heidari M. The effect of continuous care model on quality of life of patients after coronary angioplasty in Bou Ali Sina hospital. Evidence Based Care. 2014;4(1):61-70.10.22038/ebcj.2014.2396

Ale OK, Busari AA, Irokosu ES, Akinyede AA, Usman SO, Olayem SO. Medication nonadherence in Nigerian heart failure patients: A cross sectional study. Journal of Clinical Sciences. 2021;18(3):155-60.10.4103/jcls.jcls_1_21

Pallangyo P, Millinga J, Bhalia S, Mkojera Z, Misidai N, Swai HJ, et al. Medication adherence and survival among hospitalized heart failure patients in a tertiary hospital in Tanzania: a prospective cohort study. BMC research notes. 2020;13:1-8.10.1186/s13104-020-04959-w.

van der Wal MH, Jaarsma T, van Veldhuisen DJ. Non‐compliance in patients with heart failure; how can we manage it? European journal of heart failure. 2005;7(1):5-17.10.1016/j.ejheart.2004.04.007.

Adu C, Mensah KA, AhinkorahBO, Osei D, Tetteh AW, Seidu A-A. Socio-demographic factors associated with medication adherence among People Living with HIV in the Kumasi Metropolis, Ghana. AIDS Research and Therapy. 2022;19(1):50.10.1186/s12981-022-00474-z

Meraz R, McGee J, Ke W, Osteen K. Resilience mediates the effects of self‐care activation and hope on medication adherence in heart failure patients. Research in nursing & health. 2023;46(3):323-35.10.1002/nur.22312

Feehan M, Morrison MA, Tak C, Morisky DE, DeAngelis MM, Munger MA. Factors predicting self-reported medication low adherence in a large sample of adults in the US general population: a cross-sectional study. BMJ open. 2017;7(6):e014435.10.1136/bmjopen-2016-014435

Eisele M, Harder M, Rakebrandt A, Boczor S, Marx G, Blozik E, et al. Association of depression and anxiety with adherence in primary care patients with heart failure—cross-sectional results of the observational RECODE-HF cohort study. Family Practice. 2020;37(5):695-702.10.1093/fampra/cmaa042.

Basheti IA, El Hait SS, Qunaibi EA, Aburuz S, Bulatova N. Associations between patient factors and medication adherence: a Jordanian experience. Pharmacy Practice (Granada). 2016;14(1):0-.10.18549/PharmPract.2016.01.639.

Rezaei S, Vaezi F, Afzal G, Naderi N, Mehralian G. Medication adherence and health literacy in patients with heart failure: a cross-sectional survey in Iran. HLRP: Health Literacy Research and Practice. 2022;6(3):e191-e9.10.3928/24748307-20220718-02.

Jarrah M, Khader Y, Alkouri O, Al-Bashaireh A, Alhalaiqa F, Al Marzouqi A, et al. Medication Adherence and Its Influencing Factors among Patients with Heart Failure: A Cross Sectional Study. Medicina (Lithuania). 2023;59(5).10.3390/medicina59050960

Hussein D, Jima AK, Geleta LA, Gashaw K, Girma D, Ibrahim SM, et al. Medication adherence and associated factors among chronic heart failure patients on follow-up in north Shewa public hospitals, Oromia region, Ethiopia. BMC Cardiovascular Disorders. 2024;24(1).10.1186/s12872-024-04090-9

Amininasab SS, Lolaty HA, Moosazadeh M, Shafipour V. Medication adherence and its predictors among patients with heart failure. Nursing and Midwifery Studies. 2018;7(2):81-6.10.4103/NMS.NMS_9_17

Nural N, Kayhan SA. Factors Associated with Adherence to Medications, Diet and Self-Monitoring in Patients with Heart Failure. Pakistan Heart Journal. 2022;55(2):134-9.10.47144/phj.v55i2.2238

Raimi T. Factors influencing medication adherence among patients with diabetes mellitus and hypertension in Nigeria. European Journal of Biology and Medical Science Research. 2017;5(7):18-26

Cortaredona S, Ventelou B. The extra cost of comorbidity: multiple illnesses and the economic burden of non-communicable diseases. BMC medicine. 2017;15:1-11.10.1186/s12916-017-0978-2.

Adedoyin RA, Adesoye AT. Incidence and pattern of cardiovascular disease in a Nigerian teaching hospital. Tropical doctor. 2005;35(2):104-.10.1258/0049475054037075.

Seid E, Engidawork E, Alebachew M, Mekonnen D, Berha AB. Evaluationof drug therapy problems, medication adherence and treatment satisfaction among heart failure patients on follow-up at a tertiary care hospital in Ethiopia. PLoS ONE. 2020;15(8 August).10.1371/journal.pone.0237781

Kusaslan Avci D. Evaluation of the relationship between loneliness and medication adherence in patients with diabetes mellitus: A cross-sectional study. Journal of International Medical Research. 2018;46(8):3149-61.https://doi.org/10.1177/0300060518773223

Amininasab SS, Lolaty HA, Moosazadeh M, Shafipour V. The relationship between human dignity and medication adherence in patients with heart failure. Journal of Medical Ethics and History of Medicine. 2017;10:5

Eghbali M, Akbari M, Seify K, Fakhrolmobasheri M, Heidarpour M, RoohafzaH, et al. Evaluation of Psychological Distress, Self-Care, and Medication Adherence in Association with Hypertension Control. Int J Hypertens. 2022;2022:7802792.10.1155/2022/7802792

Z Malak M, J Al-thbetat A, M AL-Amer R. Psychosocial factors correlate with adherence to medications among cardiovascular outpatient clinics in Jordan. Journal of Public Health. 2023;45(1):206-13.10.1093/pubmed/fdab356.

Sandoval D, Nazzal C, Romero T. Clinical, socioeconomic, and psychosocial factors associated with blood pressure control and adherence: results from a multidisciplinary cardiovascular national program providing universal coverage in a developing country. International Journal of Hypertension. 2018;2018(1):5634352

Sandoval D, Chacón J, Muñoz R, Henríquez Ó, Koch E, Romero T. Influence of psychosocial factors on adherence to antihypertensive drug therapy. Results from a Cardiovascular Health Program cohort followed in the Metropolitan Region of Santiago, Chile Influencia de factores psicosociales enla adherencia al tratamient. 2014.10.4067/S0034-98872014001000003.

Marx G, Witte N, Himmel W, Kühnel S, Simmenroth-Nayda A, Koschack J. Accepting the unacceptable: medication adherence and different types of action patterns among patients with high blood pressure. Patient education and counseling. 2011;85(3):468-74.10.1016/j.pec.2011.04.011

Gallagher R, Luttik M-L, Jaarsma T. Social support and self-care in heart failure. Journal of Cardiovascular Nursing. 2011;26(6):439-45.10.1097/JCN.0b013e31820984e1

Tsige AW, Endalifer BL, Habteweld HA, Wondmkun YT, Ayele SG, Kefale B. Treatment satisfaction and medication adherence and predictors among patients with heart failure in Ethiopia: a hospital-based cross-sectional study. Frontiers in Pharmacology. 2024;15:1399177.10.3389/fphar.2024.1399177

Stoehr GP, Lu S-Y, Lavery L, Vander Bilt J, Saxton JA, Chang C-CH, Ganguli M. Factors associated with adherence to medication regimens in older primary care patients: the Steel Valley Seniors Survey. The American journal of geriatric pharmacotherapy. 2008;6(5):255-63.10.1016/j.amjopharm.2008.11.001.

Abebe A, Wobie Y, Kebede B, Wale A, Destaw A, Ambaye AS. Self-care practice and glycemic Control among type 2 diabetes patients on follow up in a developing country: a prospective observational study. J Diabetes Metab Disord. 2022;21(1):455-61.10.1007/s40200-022-00995-4

Farrell B, French Merkley V, Ingar N. Reducing pill burden and helping with medication awareness to improve adherence. Canadian Pharmacists Journal/Revue des Pharmaciens du Canada. 2013;146(5):262-9.https://doi.org/10.1177/1715163513500208

Huber M, Busch AK, Stalder-Ochsner I, Flammer AJ, Schmid-Mohler G. Medication adherence in adults after hospitalization for heart failure: A cross-sectional study. International Journal of Cardiology Cardiovascular Risk and Prevention. 2024;20:200234.10.1016/j.ijcrp.2023.200234.

Gellad WF, Grenard JL, Marcum ZA. A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity. The American journal of geriatric pharmacotherapy. 2011;9(1):11-23.10.1016/j.amjopharm.2011.02.004.

Persell SD, Karmali KN, Lee JY, Lazar D, Brown T, Friesema EM, Wolf MS. Associations between health literacy and medication self-management among community health center patients with uncontrolled hypertension. Patient preference and adherence. 2020:87-95.10.2147/PPA.S226619.

Aggarwal B, Pender A, Mosca L, Mochari-Greenberger H. Factors associated with medication adherence among heart failure patients and their caregivers. Journal of nursing education and practice. 2015;5(3):22.10.5430/jnep.v5n3p22.

Arnipalli H, Bala S, Pandve H. Medication Adherence and Its Determinants among Women of Cardiovascular Disease ofTertiary Care Hospital, Hyderabad. Indian Journal of Cardiovascular Disease in Women. 2020;5(04):315-21.10.1055/s-0040-1708573

Khatib R, Marshall K, Silcock J, Forrest C, Hall AS. Adherence to coronary artery disease secondary prevention medicines: exploring modifiable barriers. Open Heart. 2019;6(2):e000997.10.1136/openhrt-2018-000997