Fibroscan Study In Relation To Liver Function Test In Cases Of Hemoglobinopathies

Authors

  • Sharique Uddin Khan Rajendra Institute of Medical Sciences, Ranchi
  • Surabhi Baxla Rajendra Institute of Medical Sciences, Ranchi
  • Sunanda Jha Rajendra Institute of Medical Sciences, Ranchi
  • Amar Verma Rajendra Institute of Medical Sciences, Ranchi
  • Shabi Akhtar Jawaharlal Nehru Medical College & Hospital, Aligarh

DOI:

https://doi.org/10.37506/gxz6er25

Keywords:

Fibro scan, Liver fibrosis, LFT.

Abstract

Introduction:

Hemoglobinopathies are the most common single gene disorders. Beta-thalassemia is one of the most common hemoglobinopathies worldwide, and a high prevalence is seen in Mediterranean region, central Asia, India, and Far East countries. Recurrent ischemic insults with parenchymal necrosis can result in hepatic fibrosis, chronic liver disease, and cirrhosis. Liver biopsy has historically been the primary means to evaluate for fibrosis and monitor disease progression, but it has significant limitations. Vibration controlled transient elastrography (VCTE) utilizing fibro scan uses an ultrasound transducer probe to create an elastic shear wave through vibrations of mild amplitude and low frequency (50Hz) which are transmitted through liver tissue.

Material & Methods:

Hospital based cross sectional study was conducted involving patients under 18 years of age registered for treatment of haemoglobinathies in the Department of Pediatrics, of Rajendra Institute of Medical Sciences, Ranchi during June 2021 to June 2022.

Result:

It was observed that AST, ALT & ALP showed some progressive increase with increase in stage of fibrosis. Higher incidence of liver fibrosis was observed as patients age advances.

Conclusion:

Fibroscan is a recent technology which could detect the earliest changes in hepatic pathology without invasion, it is a painless technique and correlates well with changes in hepatic enzyme leading to identification of pathologic changes.

References

Flint J, Harding RM, Boyce AJ, et al. The population genetics of the haemoglobinopathies. Baillieres Clin Haematol 1998; 11:1–51.

Brittenham GM, Cohen AR, McLaren CE, et al. Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am J Hematol 1993; 42:81–85.

Olynyk JK, St Pierre TG, Britton RS, et al. Duration of hepatic iron exposure increases the risk of significant fibrosis in hered- itary hemochromatosis: a new role for magnetic resonance im- aging. Am J Gastroenterol 2005; 100:837–841.

Pipaliya N, Solanke D, Parikh P, Ingle M, Sharma R, Sharma S, Sawant P. Comparison of Tissue Elastography with Magnetic Resonance Imaging T2* and Serum Ferritin Quantification in Detecting Liver Iron Overload in Patients with Thalassemia Major. Clin Gastroenterol Hepatol. 2017 Feb;15(2):292-298.

Emre S, Kitibayashi K, Schwartz ME, et al. Liver transplantation in a patient with acute liver failure due to sickle cell intrahepatic cholestasis. Transplantation 2000; 69(4):675–6.

D’Ambrosio R, Maggioni M, Graziadei G. Chronic cholestasis in a patient with sickle-cell anemia: histological findings. Dig Liver Dis 2016;48(11):1402.

Cadranel JF, Rufat P, Degos F. Practices of liver biopsy in France: results of a prospective nationwide survey. For the Group of Epidemiology of the French Association for the Study of the Liver (AFEF). Hepatology 2000; 32:477-481.

Afdhal NH. Diagnosing fibrosis in hepatitis C: is the pendulum swinging from biopsy to blood tests Hepatology 2003; 37:972-974.

Regev A, Berho M, Jeffers LJ, et al. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol 2002; 97:2614-2618.

Sandrin L, Fourquet B, Hasquenoph JM, et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003; 29:1705-1713.

Castera L, Forns X, Alberti A. Non-invasive evaluation of liver fibrosis using transient elastography. J Hepatol 2008; 48:835-847.

Al-Khabori M, Daar S, Al-Busafid SA, Al-Dhuhlie H, Alumairif AA, Hassana M, Al-Rahbig S, Al-Ajmie U (2019) Noninvasive assessment and risk factors of liver fibrosis in patients with thalassemia major using shear wave elastography. Hematology 24(1):183–188.

Ahmed Z, Ahmed U, Walayat S, Ren J, Martin DK, Moole H, Koppe S, Yong S, Dhillon S (2018) Liver function tests in identifying patients with liver disease. Dovepress 11:301–307.

Giovanna Ferraioli, Raffaella Lissandrin, Carmine Tinelli, Luigia Scudeller, Federico Bonetti, Mabel Zicchetti, Filomena Longo, Mauro Murgia, Stefano Bernuzzi, Marco Zecca, Paolo Casula, Antonio Piga, Carlo Filice, Liver stiffness assessed by transient elastography in patients with β thalassaemia major, Annals of Hepatology, Volume 15, Issue 3, 2016, Pages 410-417.

Remacha A, Sanz C, Contreras E, De Heredia CD, Grifols JR, Lozano M, Nuñez GM, Salinas R, Corral M, Villegas A (2013) Spanish society of blood transfusion. Spanish society of haematology and haemotherapy. Guidelines on haemovigilance of post-transfusional iron overload. Blood Transfus 11(1):128–129.

Tari K, Abbaszadehdibavar M, Atashi A, Jalili A, Gheidishahran M (2018) Thalassemia an update: molecular basis, clinical features and treatment. Int J Biomed Public Health 1(1):48–58.

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Published

2024-09-20

How to Cite

Fibroscan Study In Relation To Liver Function Test In Cases Of Hemoglobinopathies. (2024). Indian Journal of Public Health Research & Development, 15(4), 376-381. https://doi.org/10.37506/gxz6er25