D-dimer a Clue for Severe Dengue / Dengue Shock Syndrome, An Observational Study

Authors

  • Aniket Khaladkar BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India.
  • Suvarna Patil BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India.
  • Amey Paranjape BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India
  • Pravin Jagtap BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India
  • Balaji Asole BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India
  • Bishav Singh BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India
  • Ajit Nandoskar BKL Walawalkar Hospital and Rural Medical College, Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

DOI:

https://doi.org/10.37506/dbq62p87

Keywords:

D-dimer, dengue haemorrhagic fever, platelet

Abstract

Background: Dengue fever, a mosquito-borne viral infection, poses a significant public health threat, particularly in tropical and subtropical regions. Caused by five serotypes of the dengue virus (DENV-1 to DENV-5), it affects an estimated 400 million people annually, leading to severe illness in around 96 million [1]. Dengue's clinical spectrum ranges from asymptomatic infection to mild febrile illness with flu-like symptoms, to severe dengue (SD) and dengue shock syndrome (DSS), characterized by plasma leakage, thrombocytopenia, and organ dysfunction [2].

Objective: To evaluate the correlation and diagnostic accuracy of D-dimer in differentiating severe dengue and dengue shock syndrome (SD/DSS) from mild dengue.

Method: This is an observational study carried in BKL Walawalkar medical college for a period of 6 months. 125 patients were enrolled in the study which were diagnosed as Dengue positive (NS1, IG-G, IG-M) after taking their informed consent. Dimer, platelet creatinine, SGOT SGPT levels were monitored.

Conclusion: The present study provides strong evidence for a link between D-dimer levels and the severity of dengue infection and it also address the   correlation of low platelet count and high D dimer levels. This suggests that D-dimer could be a valuable marker for assessing dengue severity.

Author Biographies

  • Aniket Khaladkar, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India.

    Post Graduate Student,Department of Medicine, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

  • Suvarna Patil, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India.

    Professor, Department of Medicine, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

     

  • Amey Paranjape, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

    Associate Professor, Department of Respiratory Medicine, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

  • Pravin Jagtap, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

    Post Graduate Student,Department of Medicine, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

  • Balaji Asole, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

    Post Graduate Student,Department of Medicine, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

  • Bishav Singh, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

    Post Graduate Student,Department of Medicine, BKL Walawalkar Hospital and Rural Medical College,  Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

  • Ajit Nandoskar, BKL Walawalkar Hospital and Rural Medical College, Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

    Biochemist, Regional Centre for Adolescent Health and Nutrition, BKL Walawalkar Hospital and Rural Medical College, Sawarde, Taluka-Chiplun,  District-Ratnagiri,  Maharashtra, India

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Published

2025-01-07

How to Cite

D-dimer a Clue for Severe Dengue / Dengue Shock Syndrome, An Observational Study. (2025). Indian Journal of Public Health Research & Development, 16(1), 47-52. https://doi.org/10.37506/dbq62p87