Extremely High Triglyceride In A Beta Thalassemia Minor Patient: A Case Report

Authors

  • Anannya Ghosh Suraksha Diagnostics Pvt Ltd
  • Sanchayan Sinha College of Medicine and Sagore Dutta Hospital, Kolkata.
  • Neepa Chowdhury Suraksha Diagnostics Pvt Ltd

DOI:

https://doi.org/10.37506/1n8a8s23

Keywords:

hypertriglyceridemia, thalassemia, atherosclerosis

Abstract

Introduction: hypertriglyceridemia in pediatric population whether familial or acquired is associated with Diabetes Mellitus type 1, uremia, hypothyroidism, nephrotic syndrome etc. abnormal serum lipid levels are associated with premature atherosclerosis. It is also seen that there is an association of hypertriglyceridemia with beta thalassemia in some cases which indicates the poor prognosis.

Materials and methods: in this context here, we are reporting a case of beta thalassemia minor with extremely high triglyceride level. A 2-year-old male child with history of failure to thrive and mild to moderate anemia was investigated for complete blood count (CBC), hemoglobin typing, lipid profile, renal function test, liver function test, thyroid profile and the electrolytes.

Result: The Hb typing showed elevated HbA2, CBC showed microcytic hypochromic anemia, triglyceride level was 2010 mg/dl. His father and mother are both beta thalassemia minor patient

Conclusion: as hypertriglyceridemia in beta thalassemia is reversible, care should be taken to prevent persistent hypertriglyceridemia which increases chance of atherosclerosis and pancreatitis

Author Biographies

  • Anannya Ghosh, Suraksha Diagnostics Pvt Ltd

    Consultant Biochemist, Suraksha Diagnostics Pvt Ltd

  • Sanchayan Sinha, College of Medicine and Sagore Dutta Hospital, Kolkata.

    Demonstrator, Department of Biochemistry, College of Medicine and Sagore Dutta Hospital, Kolkata.

  • Neepa Chowdhury, Suraksha Diagnostics Pvt Ltd

    Consultant Biochemist, Suraksha Diagnostics Pvt Ltd

References

Gomber S, Kela K, Rahiman. Hypertriglyceridemia thalassemia syndrome. Ann Trop Med 1996;16(4):359–360.

Maioli M, Pettinato S, Cherchi GM, Giraudi D, Pacifico A, Pupita G, Tidore MG. Plasma lipids in beta-thalassemia minor. Atherosclerosis. 1989;75(2-3):245-8. doi: 10.1016/0021-9150(89)90182-2. PMID: 2712866.

Yadav SS, Panchal P, Menon KC. Prevalence and Management of β-Thalassemia in India. Hemoglobin. 2022;46(1):27-32. doi: 10.1080/03630269.2021.2001346. Epub 2022 Feb 7. PMID: 35129043.

Schiettecatte J, Anckaert E, Smitz J. Interferences in Immunoassays [Internet]. Advances in Immunoassay Technology. InTech; 2012. Available from: http://dx.doi.org/10.5772/35797

Nikolac N. Lipemia: causes, interference mechanisms, detection and management. Biochem Med (Zagreb). 2014;24(1):57-67. doi: 10.11613/BM.2014.008. PMID: 24627715; PMCID: PMC393

Afonso C.B., Spickett C.M. Lipoproteins as Targets and Markers of Lipoxidation. Redox Biol. 2019;23:101. doi: 10.1016/j.redox.2018.101066

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Published

2025-01-07

How to Cite

Extremely High Triglyceride In A Beta Thalassemia Minor Patient: A Case Report. (2025). Indian Journal of Public Health Research & Development, 16(1), 1-5. https://doi.org/10.37506/1n8a8s23