Clinical Study of Lipid Profile in Intracerebral Haemorrhage in Tertiary care Center

Authors

  • Thimmineni Haritha Chalmeda AnandRao Institute of Medical Sciences, Karimnagar
  • Sanjaykumar Kaminwar Chalmeda Anand Rao Institute of Medical Sciences
  • Anish Reddy P Chalmeda Anand Rao Institute of Medical Sciences
  • Eshwaraiah Vanaparthy Chalmeda Anand Rao Institute of Medical Sciences
  • Sunil Chowdary M Chalmeda Anand Rao Institute of Medical Sciences

DOI:

https://doi.org/10.37506/aajqa435

Keywords:

Intracerebral haemorrhage, lipid profile, serum cholesterol, triglyceride, HDL-C, LDL-C, VLDL-C

Abstract

Background: Stroke caused by Intracerebral haemorrhage (ICH) has high mortality rate. Among various risk factors for ICH, hypertension is the most important factor. Certain population studies have reported a paradox of inverse association between serum cholesterol and risk of ICH.

Aims and objectives: The study aim was to evaluate the serum lipid profile total cholesterol (TC), triglycerides (TGL), high density cholesterol (HDL-C), very low density cholesterol (VLDL-C) and low density cholesterol (LDL-C) in intracerebral haemorrhage patients and look for correlation.

Methods: 50 patients with ICH admitted in Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar who fulfilled the inclusion and exclusion criteria were selected. The study design was a hospital based observational clinical study. History, clinical examination and investigations (CT & MRI Brain and basic blood biochemistry with serum lipid profile) were collected and the data were analysed statistically.

Results: Majority of the ICH patients in our study were >55 years and were males. The total serum cholesterol was < 200mg/dl in 72 % of our patients, with a mean of 168.09 ±43.74mg%. Serum triglyceride level was patients, with mean of 108.26±43.31mg%. HDL-C was < 40 mg/dl in 76% of patients and VLDL-C was < 30mg/dl in 72% patients. The various lipid fractions observed were found to be low in majority of our ICH patients (p value < 0.05), suggesting a negative association between the two. The results obtained were comparable to other similar studies.

Conclusion: Majority of intracerebral haemorrhage patients in our study had lower levels of total cholesterol, triglyceride, HDL-C, LDL-C and VLDL-C. Whether the inverse association between serum lipid levels and ICH is a true causal association or only by chance due to other common confounding factors needs to be evaluated with large scale studies.

Author Biographies

  • Thimmineni Haritha, Chalmeda AnandRao Institute of Medical Sciences, Karimnagar

    Asst.Professor 

    Department of Neurology

    Chalmeda Anand Rao Institute of Medical Sciences

    Karimnagar-505001

    Telangana, India.

  • Sanjaykumar Kaminwar , Chalmeda Anand Rao Institute of Medical Sciences

    Assoc. Professor

    Department of Neurology

    Chalmeda Anand Rao Institute of Medical Sciences

    Karimnagar-505001

    Telangana, India

  • Anish Reddy P , Chalmeda Anand Rao Institute of Medical Sciences

    Assoc.Professor

    Department of General Medicine

    Chalmeda Anand Rao Institute of Medical Sciences

    Karimnagar-505001

    Telangana, India

  • Eshwaraiah Vanaparthy , Chalmeda Anand Rao Institute of Medical Sciences

    Resident

    Department of Neurology

    Chalmeda Anand Rao Institute of Medical Sciences

    Karimnagar-505001

    Telangana, India

  • Sunil Chowdary M, Chalmeda Anand Rao Institute of Medical Sciences

    Resident

    Department of Neurology

    Chalmeda Anand Rao Institute of Medical Sciences

    Karimnagar-505001

    Telangana, India

References

Feigin VL, Lawes CM, Bennett DA, et al. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol. 2009; 8(4):355–69. doi: 10.1016/S1474-4422(09)70025-0.

Bowman T, Sesso H, Ma J, Kurth T, et al. Cholesterol and the Risk of Ischemic Stroke. Stroke. 2003; 34:2930–4.

Iribarren C, Jacobs DR, Sadler M, Claxton AJ, Sidney S. Low total serum cholesterol and intracerebral hemorrhagic stroke: is the association. Confined to elderly men? The Kaiser Permanente Medical Care Program. Stroke. 1996; 27:1993–1998.

Daniel Woo, Laura R. Sauerbeck, Brett M. Kissela, Jane C. Khoury, Jerzy P. Szaflarski, James Gebel, Rakesh Shukla, Arthur M. Pancioli, Edward C. Jauch, Anil G. Menon, Ranjan Deka Janice A. Carrozzella, Charles J. Moomaw, Robert N. Fontaine and Joseph P. Broderick et al Genetic and Environmental Risk Factors for Intracerebral Hemorrhage: Preliminary Results of a Population-Based Study Stroke. 2002; 33:1190-1196.

Sunil K. Narayan, P. Sivaprasad, Sharma Sushma, Ratnakar K. Sahoo, Tarun Kumar Dutta Etiology and outcome determinants of intracerebral hemorrhage in a south Indian population, A hospital-based study. Annals Indian Academy Neurol. 2012; 15(4):263-266.

Amanda G. Thrift, Geoffrey A. Donnan, and John J. McNeil Epidemiology of Intracerebral Hemorrhage Epidemiol Rev. 1995; 17(2):361-381.

Ashraf V. Valappil, Nilesh V. Chaudhary L, Praveenkumar R, Biju Gopalakrishnan, Girija Low cholesterol as a risk factor for primary intracerebral hemorrhage: A case control study Ann Indian Acad Neurol 2012; 15(1):19-22.

Iso H, Jacobs DR Jr, Wentworth D, Neaton JD, Cohen JD: Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the Multiple Risk Factor Intervention Trial. N Engl J Med 1989; 320:904-910.

K Yano, D M Reed and C J MacLean, Serum cholesterol and hemorrhagic stroke in the Honolulu Heart Program. Stroke. 1989; 20:1460-1465.

Konishi M, Sankai and M Ito, H Iso, Komachi, Iida, Shimamoto, Jacobs, Terao, Baba,Associations of serum total cholesterol, different types of stroke, and stenosis distribution cerebral arteries. The Akita Pathology Study. Stroke.1993; 24:954-964.

Jared D. Sturgeon, Aaron R. Folsom, W.T. Longstreth, Jr, Eyal Shahar, Wayne D. Rosamond Risk Factors for Intracerebral Hemorrhage in a Pooled Prospective Study Stroke. 2007; 38: 2718-2725.

Izumi, Hitoshi Ohta, Hiroyuki Noda, Hiroyasu Iso, Fujiko Irie, Toshimi Sairenchi, Emiko Ohtaka, Mikio Doi, Yoko Low-Density Lipoprotein Cholesterol Concentrations and Death Due to Intraparenchymal Hemorrhage: The Ibaraki Prefectural Health Study Circulation. 2009; 119:2136-2145.

Hiroyuki Noda, Hiroyasu Iso, Fujiko Irie, Yoko Izumi, Mikio Doi, Toshimi Sairenchi, Emiko Ohtaka, Hitoshi Ohta. Low-Density Lipoprotein Cholesterol Concentrations and Death Due to Intraparenchymal Hemorrhage: The Ibaraki Prefectural Health Study. Circulation. 2009; 120:e294.

Downloads

Published

2025-01-07

How to Cite

Clinical Study of Lipid Profile in Intracerebral Haemorrhage in Tertiary care Center. (2025). Indian Journal of Public Health Research & Development, 16(1), 435-440. https://doi.org/10.37506/aajqa435