Clinicopathological study of Xanthogranulomatous oophoritis-a 6-year retrospective study in a tertiary care hospital

Authors

DOI:

https://doi.org/10.37506/mfvdkx08

Keywords:

ovary, oophoritis, pelvic mass, xanthogranuloma

Abstract

Background: Xanthogranulomatous oophoritis is a rare chronic inflammatory process involving ovary .Essentially it affects ovaries alone and or fallopian tubes focally or entirely forming and adnexal mass in the pelvic cavity. In this study, we aimed to analyse the clinicopathological features of xanthogranulomatous oophoritis and its prognostic implication.

Methods: This was a retrospective study conducted over a period of 6years.A total of 18 cases were evaluated.

Result: Xanthogranulomatous oophoritis was seen most commonly in the age group of 41-50 years. Abdominal pain was the most common clinical presentation. Microscopically there was chronic inflammatory cells, foamy histiocytes and multinucleated giant cells in the ovarian stroma. Though histopathological examination is gold standard procedure, combined routine histopathology and immunohistochemistry was required for  a conclusive diagnosis in difficult cases.

Conclusion: To conclude, though the condition is rare, due to its tendency to extend to the surrounding tissues and formation of mass lesion, it closely mimics ovarian malignancy both clinically and radiologically leading to close follow up of these patients for optimal patient care.

Author Biographies

  • Rajashree Pradhan, College of Medicine And Sagore Dutta Hospital

    Associate  Professor, Department of Pathology, College of Medicine and Sagore Dutta Hospital,Kolkata, West Bengal.India

  • Sounak Rakshit, College of Medicine And Sagore Dutta Hospital

    Post graduate trainee, Department of Pathology, College of Medicine and Sagore Dutta Hospital ,Kolkata, West Bengal. India

  • Chitra Halder, College of Medicine And Sagore Dutta Hospital

    Post graduate trainee, Department of Pathology, College of Medicine and Sagore Dutta Hospital ,Kolkata, West Bengal. India

  • Upasana Mukherjee, College of Medicine And Sagore Dutta Hospital

    Senior Resident, Department of Pathology, College of Medicine and Sagore Dutta Hospital,,Kolkata,West Bengal 700058 India

References

Bhatnagar K, Narang V, Garg B, Sood N. Xanthogranulomatous Oophoritis: A Rare Case Report. Iranian Journal of Pathology [Internet]. 2018 [cited 2024 Jul 31];13(3):372–6. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322522/

Sibbald CA, Cooney LG, Molot RJ, Pellicer DL. Xanthogranulomatous oophoritis mimicking a dermoid cyst with ovarian torsion: A case report and review of the literature. Case Reports in Women s Health. 2024 Jun 1;42:e00603–3.

Xanthogranulomatous oophoritis [Internet]. www.pathologyoutlines.com. Available from: https://www.pathologyoutlines.com/topic/ovarynontumorxanthogranoophoritis.html Accessed July 26th, 2024.

Zhang X, Dong H, Zhang L, Mohamed Mokhtar Desouki, Zhao C. Xanthogranulomatous Inflammation of the Female Genital Tract: Report of Three Cases. Journal of Cancer. 2012 Jan 1;3:100–6.

Khan B, Aziz AB, Ahmed R. Case OfXanthogranulomatous Oophoritis. Journal of Ayub Medical College, Abbottabad: JAMC [Internet]. 2017 [cited 2024 Jul 31];29(1):162–4. Available from: https://pubmed.ncbi.nlm.nih.gov/28712201/

Keval Arvindbhai Patel, Chothani KP, Patel B, Lanjewar DN. Xanthogranulomatoussalpingo-oophoritis: a case report and review of literature. International journal of reproduction, contraception, obstetrics and gynecology. 2020 Sep 25;9(10):4316–6.

Elahi AA, Nigam A, Pujani M, Batra S. Xanthogranulomatous oophoritis mimicking malignancy: a diagnostic dilemma. BMJ case reports [Internet]. 2015 Jun 1 [cited 2024 Jul 31];2015:bcr2015210642. Available from: https://europepmc.org/article/med/26113594

U MK, Rm P, Br Y, Pande P. Xanthogranulomatous Oophoritis - Masquerading as Ovarian Neoplasm. Asian Journal of Pharmaceutical and Health Sciences [Internet]. 2012 [cited 2024 Jul 31];2(2). Available from: https://ajphs.com/article/2012/2/2/308-309

Pujani M, Singh S, Pujani M, Shukla S. Xanthogranulomatous oophoritis associated with primary infertility and endometriosis. Indian Journal of Pathology and Microbiology. 2010;53(1):197.

Swati Girdher, Ahuja S, Saba Naaz, Ahluwalia C, Amit Kumar Yadav, Zaheer S. Xanthogranulomatous oophoritis: A case series and literature review. Journal of medicine, surgery, and public health. 2023 Jan 1;1:100016–6.

J;Raetskaya-Solntseva S. Xanthogranulomatous Oophoritis Presenting as an Adnexal Mass and Bowel Obstruction. A Case Report. The Journal of reproductive medicine [Internet]. 2015 [cited 2024 Aug 20];60(5-6). Available from: https://pubmed.ncbi.nlm.nih.gov/26126317/

Raj JA, Jagadeesha M, Naveen S, Ramachandra U. Xanthogranulomatous oophoritis: pathologic findings with clinical correlation. Journal of the Indian Medical Association [Internet]. 2012 Sep 1 [cited 2024 Jul 31];110(9):653–4. Available from: https://pubmed.ncbi.nlm.nih.gov/23741842/

Yener N, Ilter E, Midi A. Xanthogranulomatous salpingitis as a rare pathologic aspect of chronic active pelvic inflammatory disease. Indian Journal of Pathology and Microbiology. 2011;54(1):141.

Gami N, Mundhra R, Guleria K, Arora VK, Garg S. Recurrent pyometra and xanthogranulomatous salpingitis: A rare pathologic association in a postmenopausal lady. Journal of Mid-Life Health [Internet]. 2014 [cited 2024 Jul 31];5(3):156–8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195190/

Ara A, Sharma C, Chawla I, Ahuja A. Xanthogranulomatous Oophoritis, a Dilemma. Journal of South Asian Federation of Obstetrics and Gynaecology [Internet]. 2023 Jul 31 [cited 2024 Jul 31];15(3):357–8. Available from: https://www.jsafog.com/abstractArticleContentBrowse/JSAFOG/6/15/3/33264/abstractArticle/Article

Dawande P, Wankhade R, Pande M. Xanthogranulomatous Oophoritis: A Rare Case Report. Cureus [Internet]. [cited 2024 Jul 31];15(8):e43724. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505683/

Rawal G, Zaheer S, Dhawan I. Xanthogranulomatous Oophoritis Mimicking an Ovarian Neoplasm: A Rare Case Report. Journal of Mid-Life Health [Internet]. 2018 [cited 2024 Jul 31];9(1):41–3. Available from: https://pubmed.ncbi.nlm.nih.gov/29628729/

Krishna M. Xanthogranulomatus inflammatory lesion mimicker of malignancy – A clinicopathological study from rural India. Northern Clinics of Istanbul. 2021;

Mehrotra P, Ravikumar G. Xanthogranulomatous inflammation of the female genital tract: An 11-year single institutional study of 40 cases. Annals of Diagnostic Pathology. 2023 Dec 1;67:152217–7.

Downloads

Published

2025-06-07

How to Cite

Clinicopathological study of Xanthogranulomatous oophoritis-a 6-year retrospective study in a tertiary care hospital. (2025). Indian Journal of Public Health Research & Development, 16(3), 250-246. https://doi.org/10.37506/mfvdkx08