The Effects of Unani Formulation Jawarish Bisbasa in Dyslipidaemia and Anthropometric Parameters Associated with Central Obesity- An open-label clinical Trial

Authors

  • Nirmala Devi MK Regional Research Institute of Unani Medicine (RRIUM), Mumbai
  • Mohd Adil Adil Regional Research Institute of Unani Medicine
  • Nikhat Shaikh Regional Research Institute of Unani Medicine (RRIUM), Mumbai
  • Irfan Ahmad Regional Research Institute of Unani Medicine (RRIUM), Mumbai.
  • Shah Alam Regional Research Institute of Unani Medicine (RRIUM), Mumbai.
  • Piyush Yadav (Statistics), RRIUM, Mumbai.
  • Gazala Javed CCRUM Delhi

DOI:

https://doi.org/10.37506/wdzz3567

Keywords:

Hypertension, BMI,Central obesity, salt intake, bmi, hyperlipidemia

Abstract

Abstract:

The Unani system of medicine is endowed with enormous single and compound drugs and regimes for managing obesity that are safe and effective. Jawarish Bisbasa, a Unani polyherbal formulation, is traditionally used in the clinical treatment of central obesity. It is a polyherbal, semi-solid preparation of eleven medicinal herbs mainly used as spices. Though the standardized operating procedure for preparing Jawarish Bisbasa and its quality evaluation, along with stability data, have been reported, scientific documentation of the data on the safety and pharmacokinetic profile of Jawarish Bisbasa remains unexplored. One known modifiable risk factor for ischemic heart disease, stroke, and hypertension is dyslipidemia. The limitations of current conventional therapy have provided scope for research into a potential drug for this medical condition. It was hypothesized that Unani Formulation Jawarish Bisbasa may ameliorate dyslipidemia in humans.

Aim of the study: The main objective of this study was to evaluate the effect of Unani Formulation Jawarish Bisbasa and compare the changes in lipid profiles and anthropometric parameters before and after treatment in patients with hyperlipidemia associated with central obesity.

Materials and methods: An open-label clinical validation study was conducted at the Regional Research Institute of Unani Medicine, Mumbai Research OPD. The study included 120 cases of each gender with BMIs of 34.99 kg/m2 for men and 32.49 kg/m2 for women, while 88 cases completed the study. Enrolled cases received Unani Formulation Jawarish Bisbasa 7gm BD twice daily with warm water for 8 weeks. The pathological investigations and anthropometric parameters related to the study, particularly BMI, waist circumference, waist-to-hip ratio, sagittal abdominal diameter, LDL, HDL, and VLDL values, were statistically analyzed at baseline, first, follow-up, and at the end of the study by using an unpaired Student t-test and one-way analysis of variance. (ANOVA). Extremely significant BMI, waist circumference, waist-to-hip ratio, sagittal abdominal diameter, and lowering of ESR, total cholesterol, and triglycerides were analyzed in hyperlipidemia associated with central obesity. There were no side effects reported during the treatment.

Author Biographies

  • Nirmala Devi MK, Regional Research Institute of Unani Medicine (RRIUM), Mumbai

    Research Officer, Regional Research Institute of Unani Medicine (RRIUM), Mumbai

  • Nikhat Shaikh, Regional Research Institute of Unani Medicine (RRIUM), Mumbai

    Research Officer, Regional Research Institute of Unani Medicine (RRIUM), Mumbai

  • Irfan Ahmad, Regional Research Institute of Unani Medicine (RRIUM), Mumbai.

    Research Officer, Regional Research Institute of Unani Medicine (RRIUM), Mumbai

  • Shah Alam, Regional Research Institute of Unani Medicine (RRIUM), Mumbai.

    Research Officer, Regional Research Institute of Unani Medicine (RRIUM), Mumbai

  • Piyush Yadav, (Statistics), RRIUM, Mumbai.

    Investigator (Statistics), RRIUM, Mumbai,

  • Gazala Javed, CCRUM Delhi

    Assistant Director CCRUM Delhi

References

Albuquerque D, Nóbrega C, Manco L, Padez C. The contribution of genetics and environment to obesity. Br Med Bull 2017; 123:159‑73.2.

World Health Organization (WHO). Obesity and Overweight. 2021. Available from: https://www.who.int/news‑room/fact‑sheets/detail/obesity‑and‑overweight. [Last accessed on 2022 Mar 14].3.

Abbott L, Lemacks J, Greer T. Development and evaluation of a measure Salam, et al.: Obesity and overweight for social support provided by friends during lifestyle management programs. Healthcare (Basel) 2022; 10:901.

Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME. Obesity‑induced hypertension: Interaction of neurohumoral and renal mechanisms. Circ Res 2015; 116:991‑1006.5.

World Health Organization (WHO). World Obesity Day 2022 – Accelerating Action to Stop Obesity. 2022. Available from:

N. John Bosomworth. 2019. Normal-weight central obesity Unique hazard of the toxic waste. Canadian Family Physician-Le Médecin de famillecanadienVol 65: 399-408.

Sun Y, Sekine M, Kagamimori S. Lifestyle and overweight among Japanese adolescents: The Toyama birth cohort study. J Epidemiol, 2009;19:303‑10.

Kerkadi A, Sadig AH, Bawadi H, Al Thani AA, Al Chetachi W, Akram H, et al. The relationship between lifestyle factors and obesity indices among adolescents in Qatar. Int J Environ Res Public Health 2019; 16:4428.

Monika Chaudhary and Priyanshu Sharma. Abdominal obesity in India: analysis of the National Family Health Survey-5 (2019–2021) data. The Lancet Regional Health - Southeast Asia 2023;14: 100208.

Ahmer SM, Khan Rizwan Mansoor, Jamil Abu Waris, et al. Obesity (Siman-E-Mufrat) in Greaco-Arabic perspective – A review. Research & Reviews: A Journal of Unani, Siddha and Homeopathy, 2015; 2(1): 10–16p.

Jalinoos, Kitab-fi-al-Mizaj. (Edited and translated), Ibne Sina Academy, Aligarh, 2008; 137-149.

Tabri R, Firdaus-al-Hikmat, Central Council for Research in Unani Medicine publication, New Delhi, 2010; 246-248.

Raban, T., 1980. Firdous-ul-Hikmat (Urdu Translation by Hakim Rashid Ashraf Nadvi). Diamond Publications, Lahore.

Ibn-e-Sina, 1905. Alqanoon fit Tibb, 4. Matbah Nami Nawal Kishore, Lucknow. Jahangir, U., Jalees, F., Kapoor, P., Khan, A., Urooj, S., 2014. Evaluation of a classical unani pharmacopeial formulation safoof-e-muhazzil in hyperlipidemia: a randomized, standard controlled clinical study. J. Pharm. Bioallied Sci. 6, 167.

Garg, R., Aggarwal, S., Kumar, R., Sharma, G., 2015. Association of atherosclerosis with dyslipidemia and co-morbid conditions: a descriptive study. J. Nat. Sci. Biol.

GL Bairwa, ND Jasuja, SC Joshi, “Lipid-lowering and antioxidant effects of Amomum subulatum seeds (Family Zingiberaceae) in cholesterol fed rabbits”, Archives of Phytopathology and Plant Protection, vol.44, issue.14, pp.1425-1431, 2011.

A Ram, P Lauria, R Gupta, VN Sharma, “Hypolipidaemic effect of Myristica fragrans fruit extract in rabbits”, J. Ethnopharmacol., vol.55, issue.1, pp.49-53, 1996.

S Kazemi, F Yaghooblou, F Siassi, A Rahimi Foroushani, M Ghavipour, F Koohdani, G Sotoudeh, “Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and overweight pre-diabetic women: a randomized double-blind clinical trial”, J. Sci. Food Agric., vol.97, issue.15, pp.5296-5301, 2017.

U Bhandari, JN Sharma, R Zafar, “The protective action of ethanolic ginger (Zingiber officinale) extract in cholesterol-fed rabbits”, J. Ethnopharmacol., vol.61, issue.2, pp.167-171, 1998.

I Javed, I Faisal, Z Rahman, MZ Khan, F Muhammad, B Aslam, M Ahmad, A Shahzadi. “Lipid lowering effect of Cinnamomum zeylanicum in hyperlipidaemic albino rabbits”, Pak. J. Pharm. Sci., vol.25, issue.1, pp.141-147, 2012.

RS Vijayakumar, N Nalini, “Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats”, J. Basic Clin. Physiol. Pharmacol., vol.17, issue.2, pp.71-86, 2006.

SA Adefegha, G Oboh, OM Adefegha, AA Boligon, ML Athayde, “Antihyperglycemic, hypolipidemic, hepatoprotective and antioxidative effects of dietary clove (Szyzgium aromaticum) bud powder in a high-fat diet/streptozotocin-induced diabetes rat model”, J. Sci. Food Agric., vol.94, issue.13, pp.2726-2737, 2014.

Trinder, P., 1969. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann. Clin. Biochem. Int. J. Lab. Med. 6, 24–27. https:// doi.org/10.1177/000456326900600108.

Williams, P., Robinson, D., Bailey, A., 1979. High-density lipoprotein and coronary risk factors in normal men. Lancet 313, 72–75. https://doi.org/10.1016/S0140-6736 (79)90063-1.

Bradley, D.W., Maynard, J.E., Emery, G., Webster, H., 1972. Transaminase activities in serum of long-term hemodialysis patients. Clin. Chem. 18, 1442.

Wilkinson, J.H., Boutwell, J.H., Winsten, S., 1969. Evaluation of a new system for the kinetic measurement of serum glutamic oxalacetic transaminase. An interlaboratory study. Clin. Chem. 15, 496–504. https://doi.org/10.1093/clinchem/15.6.496.

Pearlman, F.C., Lee, R.T.Y., 1974. Detection and measurement of total bilirubin in serum, with use of surfactants as solubilizing agents. Clin. Chem. 20, 447–453. https://doi. org/10.1093/clinchem/20.4.447.

Tiffany, T.O., Jansen, J.M., Burtis, C.A., Overton, J.B., Scott, C.D., 1972. Enzymatic kinetic rate and end-point analyses of substrate, by use of a GeMSAEC fast analyzer. Clin. Chem. 18, 829–840. https://doi.org/10.1093/clinchem/18.8.829.

Bowers, L., 1980. Kinetic serum creatinine assays I. The role of various factors in determining specificity. Clin. Chem. 26, 551–554.

Obesity and Overweight. World Health Organization. Available

from: http://www.who.int/mediacentre/factsheets/fs311/en/.

[Last accessed on 2015 Apr 25].

Obesity and Overweight. World Health Organization. Available

from: http://www.who.int/mediacentre/factsheets/fs311/en/.

[Last accessed on 2015 Apr 25].

Obesity and Overweight. World Health Organization. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/. [Last accessed on 2015 Apr 25].

Obesity and Overweight. World Health Organization. Available

from: http://www.who.int/mediacentre/factsheets/fs311/en/.

[Last accessed on 2015 Apr 25]

Swinburn, B. A., Sacks, G., Hall, K. D., McPherson, K., Finegood, D. T., Moodie, M. L., Gortmaker, S. L. (2011). The global obesity pandemic: shaped by global drivers and local environments. The Lancet, 378(9793), 804-814.

World Health Organization Study Group. Diet, nutrition, and prevention of chronic diseases. Geneva: World Health Organization, 1990.

World Health Organization Scientific Group. Cardiovascular disease risk factors: new areas for research. Geneva: World Health Organization, 1993.

Downloads

Published

2024-09-20

How to Cite

The Effects of Unani Formulation Jawarish Bisbasa in Dyslipidaemia and Anthropometric Parameters Associated with Central Obesity- An open-label clinical Trial. (2024). Indian Journal of Public Health Research & Development, 15(4), 346-353. https://doi.org/10.37506/wdzz3567