Mentzer Index as a reliable and economical tool for screening of beta-thalassemia trait
DOI:
https://doi.org/10.37506/n4nksw89Keywords:
Iron profile, Microcytosis, ThalassemiaAbstract
ABSTRACT Introduction: Microcytic hypochromic anemia is a distinct morphologic subtype of anemia with variable etiological causes. Mentzer Index is an economical tool derived from hematology analyser readings (MCV/RBC count), which can help in distinguishing Beta thalassemia trait from other causes. Aims and objectives: The aim of this study was to evaluate the role of Mentzer Index in distinguishing Beta thalassemia trait from other causes of microcytic anemia. Methods: Five hundred cases of microcytic hypochromic anemia were randomly selected. Relevant clinical history, hemogram, reticulocyte count, iron profiles were documented. Mentzer index was calculated. MCV/RBC count >13 -suggestive of Iron Deficiency anemia. MCV/RBC count<13- suggestive of Thalassemia trait disorders. Hemoglobin electrophoresis were conducted for confirmation. Data was statistically analysed. Results: Iron deficiency anemia was the most common etiology (85%) followed by anemia of chronic diseases (12.2%). Beta thalassemia trait was detected in 2.2% cases and sideroblastic anemia was detected in 0.6 % cases. In the present study, among the 500 patients, 484 cases had Mentzer>13 while 16 cases had<13. Conclusion: Diagnosis of microcytic hypochromic anemia requires a standardized diagnostic approach which needs resources. But in resource deficient areas, Mentzer index can be used as a tool in initial screening. This calculation does not put any extra financial burden on poor patients yet provides valuable reliable information.
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