Seroprevalence & Epidemiology of Hepatitis C Virus Infections in North India: A Hospital Based Study
DOI:
https://doi.org/10.37506/w5c57q49Abstract
Background: Hepatitis C is a global health problem affecting a significant portion of the world’s population. Published data in North India on epidemiology, prevalence and risk factors is very limited. This study was carried out to estimate the seroprevalence, associated demographic factors influencing transmission and distribution of hepatitis C virus (HCV) in a hospital-based population in Punjab.
Methods: A total of 16920 serum samples were tested for anti HCV antibodies using commercially available kits, from August 2021 to August 2023. The study highlighted on different epidemiological aspects such as age groups, sexes, likely mode of transmission and probable cause for undergoing screening procedures
Results: The seroprevalence for anti-HCV-Ab was found to be 1.6%. Multiple blood transfusions, hemodialysis & IV drug abuse were significant risk factors. Sero-prevalence rate of HCV infection was significantly more prevalent (77 %) in male patients. IgM anti HCV reactivity was highest (42%) in age group of 20-40 years
Conclusions: The study findings, including the overall prevalence of HCV infection, associated risk factors and demographic characteristics, can guide prevention and control efforts against Hepatitis C .The need of the hour is to increase awareness about HCV among the public and practicing physicians
References
Ed, Fields BN, Knipe DM, Howley PM, 5th edn. Philadelphia: Lippincott- Raven, pp. 1035-1053.
Gravitz L. Introduction: a smouldering public-health crisis. Nature. 2011 Jun 8;474(7350):S2-4.
Mohd Hanafiah K, Groeger J, Flaxman A, Wiersma S (2013). Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology, 57:1333-42.
World Health Organization. Hepatitis C Fact sheet October 2017.
Gower E, Estes C, Blach S, Razavi-Shearer K, Razavi H. Global epidemiology and genotype distribution of the hepatitis C virus infection. J Hepatol. 2014; 61(1 suppl):S45–S57.
Hoofnagle JH. Course and outcome of hepatitis C. Hepatology.2002;36(5 Suppl 1):S21-9
DY-K, Lai C-L, Yuen M-F. Natural history of hepatitis-related hepatocellular carcinoma. World J Gastroenterol. 2008; 14(11):1652–1656.
Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989; 244(4902):359–362.
Mukhopadhya A. HCV: The Indian scenario. Trop Gastroenterol 2006;27:105-10.
Virk S. Punjab leads in the Hepatitis C cases. In: Times of India. 2009 May 19. Available from: htt p: www.//articles. timesofindia.indiatimes.com/2009-05-19/ludhiana/28165874_1_ needles-hepatitis-c-cases-diseases.
Goel A, Bhadauria DS, Kaul A, Verma A, Tiwari P, Rungta S, Rai P, Gupta A, Aggarwal R. Acute hepatitis C treatment in advanced renal failure using 8 weeks of pan-genotypic daclatasvir and reduced-dose sofosbuvir. Nephrol Dial Transplant. 2021 Sep 27;36(10):1867-1871.
Patil SR, Datkhile KD, Ghorpade MV, Patil SS, Kakade SV. Seroprevalence, risk factors and genotype distribution for Hepatitis C infection: a study from rural hospital in Maharashtra. Indian J Med Microbiol. 2017; 35(4):563-567.
Sood A, Midha V, Goyal O. Treatment of chronic hepatitis C genotype 1 early responders with 36 week pegylated interferon and ribavirin therapy. Ann Hepatol. 2014 Oct;13(5):503-509
Sood A, Sarin SK, Midha V, Hissar S, Sood N, Bansal P, et al. Prevalence of hepatitis C virus in a selected geographical area of northern India: A population based survey. Indian J Gastroenterol. 2012;31:232-6.
Arora D, Jindal N, Dang R, Kumar R. Rising Seroprevalence of HCV a Silent Killer–Emerging Problem. Int J Pharm Pharm Sci 2011; 3:57-9
Jaiswal, S.P., Chitnis, D.S., Jain, A.K., Inamdar, S., Porwal, A., Jain, S.C. 2001. Prevalence of hepatitis viruses among multi-transfused homogenous thalassaemia patients. Hepatol. Res., 19: 247 -53
Amarapurkar DN, Kumar A, Vaidya S, Murti P, Bichile SK, Kalro RH, Desai HG. Frequency of hepatitis B, C and D and human immunodeficiency virus infections in multi-transfused thalassemics. Indian J Gastroenterol. 1992 Apr;11(2):80-1.
Ghosh, K., Joshi, S.H., Shetty, S., Pawar, A., Chipkar, S., Pujari, V., et al. Transfusion transmitted diseases in haemophilics from western India. Indian J. Med. Res. 2000;112: 61- 4
Neogi DK, Bhattacharya N, Chakrabarti T, Mukherjee KK. HCV activity in Calcutta--a serological study. J Commun Dis. 1997 Mar;29(1):1-6. PMID: 9282522.
Sood A, Midha V, Awasthi G. Hepatitis C: Knowledge and practices among the family physicians. Trop Gastroenterol 2002;23:198-201.
Kumar A, Sharma KA, Gupta RK, Kar P, Chakravarti A. Prevalence & riskfactors forhepatitisCvirusamong pregnant women. Indian J Med Res. 2007 Sep; 126(3):211e215.
Thakral B, Marwaha N, Chawla YK, et al. Prevalence & significance of hepatitis C virus (HCV) seropositivity in blood donors. Indian J Med Res. 2006 Oct;124(4):431-438.
Mittal G, Gupta P, Gupta R, Ahuja V, Mittal M, Dhar M. Seroprevalence and risk factors of hepatitis B and hepatitis C virus infections in uttarakhand, India. J Clin Exp Hepatol. 2013 Dec;3(4):296-300
Kumar T, Shrivastava A, Kumar A, Laserson KF, Narain JP, Venkatesh S, Chauhan LS, Averhoff F. Viral Hepatitis Surveillance--India, 2011-2013. MMWR Morb Mortal Wkly Rep. 2015 Jul 24;64(28):758-62.
Sood A, Midha V, Mahajan R, Narang V, Mehta V, Wander P, Sharma S, Kaur K, Singh D. Results of sofosbuvir-based combination therapy for chronic hepatitis C cohort of Indian patients in real-life clinical practice. J Gastroenterol Hepatol. 2017 Apr;32(4):894-900.
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