Toxidromes and Their Public Health Impacts: A Cross-Sectional Analysis From a South Indian Tertiary Care Hospital

Authors

  • Sathishkumar A.G. Thanjavur Medical College
  • Vennila Sakthivel Thanjavur Medical College
  • Vennila Sakthivel Thanjavur Medical College

DOI:

https://doi.org/10.37506/c5vc6861

Keywords:

Toxidromes, Public Health, Organophosphate Poisoning, Substance Abuse

Abstract

Objective:

This study aimed to assess the prevalence, clinical features, and public health impact of various toxidromes, focusing on their demographic associations and healthcare implications in a tertiary care hospital setting.

Methods:

A hospital-based cross-sectional study was conducted over a period of one year (January 2021 - December 2021), involving patients who presented with signs of toxic exposure or poisoning. A total of 120 cases were analyzed using detailed questionnaires and clinical examinations.

Results:

The study identified that organophosphate poisoning was the most common toxidrome, accounting for 35% of the cases. Toxidromes were more prevalent in individuals aged 20-40, with a higher incidence in males. A significant correlation was found between socioeconomic factors, such as low income and education level, and the incidence of poisoning.

Conclusion:

The study underscores the significant public health burden of toxidromes, particularly in low-income areas. Early detection, public awareness campaigns, and preventive measures such as poisoning education are essential to reducing the burden of toxicological diseases.

Author Biographies

  • Sathishkumar A.G., Thanjavur Medical College

     MBBS MD Post-Graduate Student ,  Department of General Medicine, Thanjavur Medical College

  • Vennila Sakthivel , Thanjavur Medical College

    MD Senior Assistant Professor , Department of General Medicine, Thanjavur Medical College

  • Vennila Sakthivel, Thanjavur Medical College

     DDVL, MD Senior Assistant Professor, Department of General Medicine, Thanjavur Medical College

References

Hurtado D, Quintero JA, Rodríguez YA, Pérez DE, Paz RF, Diez-Sepúlveda J. Principal causes of acute poisoning in an emergency service: experience between 2014 and 2021 at a University Hospital in Southwestern Colombia. Sci Rep. 2024 Feb 12;14(1):3544.

The public health impact of chemicals: knowns and unknowns [Internet]. [cited 2025 Feb 4]. Available from: https://www.who.int/publications/i/item/WHO-FWC-PHE-EPE-16-01

Levine M, Brooks DE, Truitt CA, Wolk BJ, Boyer EW, Ruha AM. Toxicology in the ICU: Part 1: General Overview and Approach to Treatment. Chest. 2011 Sep 1;140(3):795–806.

Kobylarz D, Noga M, Frydrych A, Milan J, Morawiec A, Glaca A, et al. Antidotes in Clinical Toxicology—Critical Review. Toxics. 2023 Sep;11(9):723.

Parekh U, Gupta S. Epidemio-toxicological profile of poisoning cases - A five years retrospective study. Journal of Forensic and Legal Medicine. 2019 Jul 1;65:124–32.

Karunarathne A, Bhalla A, Sethi A, Perera U, Eddleston M. Importance of pesticides for lethal poisoning in India during 1999 to 2018: a systematic review. BMC Public Health. 2021 Jul 22;21:1441.

Anderson SF. Best (but oft forgotten) practices: sample size planning for powerful studies. The American Journal of Clinical Nutrition. 2019 Aug 1;110(2):280–95.

Wani RT. Socioeconomic status scales-modified Kuppuswamy and Udai Pareekh’s scale updated for 2019. J Family Med Prim Care. 2019 Jun;8(6):1846–9.

Mittal C, Singh S, Kumar-M P, Varthya SB. Toxicoepidemiology of poisoning exhibited in Indian population from 2010 to 2020: a systematic review and meta-analysis. BMJ Open. 2021 May 24;11(5):e045182.

A Study on the Clinical Profile of Non-Organophosphorus Poisoning in a Tertiary Care Hospital | Toxicology International [Internet]. [cited 2025 Feb 4]. Available from: https://www.informaticsjournals.co.in/index.php/toxi/article/view/35652

Singh O, Javeri Y, Juneja D, Gupta M, Singh G, Dang R. Profile and outcome of patients with acute toxicity admitted in intensive care unit: Experiences from a major corporate hospital in urban India. Indian J Anaesth. 2011 Jul;55(4):370–4.

Nadeem MN, Maqdoom M, Akif ME. A Prospective Observational Study on Pattern of Poisoning Cases Reported to Emergency Department of a Teaching Hospital in South India. Biomedical and Pharmacology Journal. 2020 Dec 30;13(4):1863–9.

Acharya A, Panda A. Clinical Epidemiology and Predictors of Outcome in Chlorpyrifos Poisoning in Farming and Allied Agricultural Workers in East Godavari, Andhra Pradesh. Indian J Occup Environ Med. 2022;26(2):116–21.

Rajbanshi LK, Arjyal B, Mandal R. Clinical Profile and Outcome of Patients with Acute Poisoning Admitted in Intensive Care Unit of Tertiary Care Center in Eastern Nepal. Indian J Crit Care Med. 2018 Oct;22(10):691–6.

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Published

2025-09-24

How to Cite

Toxidromes and Their Public Health Impacts: A Cross-Sectional Analysis From a South Indian Tertiary Care Hospital. (2025). Indian Journal of Public Health Research & Development, 16(4), 238-244. https://doi.org/10.37506/c5vc6861