Nipah virus spillover and transmission in Asia for targeted management strategies- A systematic review protocol
DOI:
https://doi.org/10.37506/wc31gj12Keywords:
Asia, Nipah Virus, Outbreak, Transmission, Zoonotic spilloverAbstract
Introduction
Nipah virus (NiV) is a zoonotic pathogen that poses a significant public health threat in Southeast and South Asia, with case fatality rates ranging from 40% to 100%. This systematic review aims to identify key transmission and spillover patterns and management strategies to help in prioritizing resource allocation and intervention.
Methods and analysis
This systematic review will be conducted following PRISMA guidelines. The search will encompass multiple electronic databases, including PubMed, Embase, and Scopus, up to 2024. Study selection, data extraction, and quality assessment will be performed by three independent reviewers, with a fourth reviewer resolving any disagreements. Data will be synthesized to identify patterns in transmission dynamics and inform targeted management strategies.
Ethics and dissemination
Ethical approval was not required as no human participants were involved. The systematic review will be published in an appropriate scientific journal.
Registration details
This systematic review has been registered on PROSPERO with registration ID CRD42024546848.
References
Nipah virus infection - India [Internet]. [cited 2024 Apr 23]. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON490
Verma A, Jain H, Sulaiman SA, Pokhrel P, Goyal A, Dave T. An impending public health threat: analysis of the recent Nipah virus outbreak and future recommendations – an editorial. Annals of Medicine and Surgery [Internet]. 2024 Feb [cited 2024 Apr 24];86(2):638. Available from: /pmc/articles/PMC10849355/
Arunkumar G, Chandni R, Mourya DT, Singh SK, Sadanandan R, Sudan P, et al. Outbreak Investigation of Nipah Virus Disease in Kerala, India, 2018. J Infect Dis [Internet]. 2019 May 24 [cited 2024 Apr 23];219(12):1867–78. Available from: https://dx.doi.org/10.1093/infdis/jiy612
Thomas B, Chandran P, Lilabi MP, George B, Sivakumar CP, Jayadev VK, et al. Nipah Virus Infection in Kozhikode, Kerala, South India, in 2018: Epidemiology of an Outbreak of an Emerging Disease. Indian J Community Med [Internet]. 2019 Oct 1 [cited 2024 Apr 23];44(4):383. Available from: /pmc/articles/PMC6881878/
Satter SM, Aquib WR, Sultana S, Sharif AR, Nazneen A, Alam MR, et al. Tackling a global epidemic threat: Nipah surveillance in Bangladesh, 2006–2021. PLoS Negl Trop Dis [Internet]. 2023 Sep 1 [cited 2024 Apr 23];17(9):e0011617. Available from: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0011617
Luby SP, Gurley ES, Hossain MJ. Transmission of human infection with Nipah Virus. Clin Infect Dis [Internet]. 2009 Dec 12 [cited 2024 May 2];49(11):1743. Available from: /pmc/articles/PMC2784122/
Nipah virus from bats - another potential pandemic? Risk mapping the impact of anthropogenic and climate change on the transmission of Nipah virus infection to humans. medRxiv [Internet]. 2022 Feb 22 [cited 2024 May 2]; Available from: https://typeset.io/papers/nipah-virus-from-bats-another-potential-pandemic-risk-1k55t988
Hegde S, Lee KH, Styczynski A, Jones FK, Gomes I, Das P, et al. Potential for person-to-person transmission of henipaviruses: A systematic review of the literature. medRxiv [Internet]. 2023 Feb 26 [cited 2024 May 2]; Available from: https://typeset.io/papers/potential-for-person-to-person-transmission-of-henipaviruses-3qvtncp6
Kulkarni DD, Tosh C, Bhatia S, Raut AA. Nipah Virus Infection. Journal of Association of Physicians of India [Internet]. 2017 Jan 1 [cited 2024 May 2];66(12):58–60. Available from: https://typeset.io/papers/nipah-virus-infection-1i4fobt3l1
Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Revista Espanola de Nutricion Humana y Dietetica. 2016;20(2):148–60.
Rayyan – Intelligent Systematic Review - Rayyan [Internet]. [cited 2024 Apr 23]. Available from: https://www.rayyan.ai/
JBI Critical Appraisal Tools | JBI [Internet]. [cited 2024 Aug 30]. Available from: https://jbi.global/critical-appraisal-tools
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Rutuparna Sibani Dandsena, Ansuman Panigrahi, Swati Sambita Mohanty, Priyanka Sahu, Jewel Ipsita Sahani, Purnashashi Behera, Narayana Swamy D M
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.