Factors Influencing Drug-Resistant Tuberculosis Treatment Outcomes in Banda District of Bundelkhand Region, Uttar Pradesh.
DOI:
https://doi.org/10.37506/pg56ee85Keywords:
: Rifampicin-resistant tuberculosis (R.R. TB), Drug-resistant tuberculosis (DR-TB), Treatment adherence.Abstract
Background: Tuberculosis (TB) is an infectious disease caused by the bacillus mycobacterium tuberculosis . Drug resistance Tuberculosis (DR-TB) is TB that is resistant to one or two first line drugs (WHO, 2023). It results from either primary infection with resistant bacteria or may develop in the course of a patient’s treatment .Different types of DR-TB are H.Mono,RR-TB,Pre-XDR and XDR. This study conducted with these
Aim & Objectives: To determine factors influencing drug-resistant tuberculosis treatment outcomes in Banda district of Bundelkhand region.
Material and Methods: This cross-sectional study explored the factors affecting treatment outcomes among drug-resistant tuberculosis (DR-TB) patients in Banda district. A total of 130 patients registered under the National Tuberculosis Elimination Program (NTEP) in Banda district of Bundelkhand region were included
Results: Among the different types of TB, rifampicin-resistant TB (R.R. TB) was the most common, affecting 68.46% of patients, followed by MDR TB at 27.69%. Least common was H.mono accounting for 1.54%. Treatment outcomes vary significantly , with H.Mono cases achieving 100% success, while pre-XDR TB cases show a poor prognosis with 66.67 death rates and no cures.
Conclusions: R.R. TB is the predominant form of drug-resistant TB, influenced by age, socioeconomic status, and addiction. Treatment outcomes are affected by adherence, stigma, and drug availability.
References
World Health Organization. (2023). Global Tuberculosis Report 2023. Geneva: World Health Organization. Retrieved from https://www.who.int/publications/i/item/9789240077664
Ministry of Health and Family Welfare, Government of India. (2023). India TB Report 2023: Coming Together to End TB. New Delhi: Central TB Division.
World Health Organization. (2022). Tuberculosis Fact Sheet. Retrieved from https://www.who.int/news-room/fact-sheets/detail/tuberculosis
Ministry of Health and Family Welfare, Government of India. (2021). National Strategic Plan for Tuberculosis Elimination 2017–2025. New Delhi: Central TB Division. Retrieved from https://tbcindia.gov.in/showfile.php?lid=3315
Collaboration with Industries to End Tuberculosis [Internet]. Available from: https://www.ihat.in/resources/collaboration-with-industries-to-end-tb/.
Bekele, A., Tsegaye, A., & Woldeamanuel, Y. (2023). Prevalence and treatment outcomes of drug-resistant tuberculosis in Ethiopia: A retrospective cohort study. Ethiopian Journal of Health Sciences, 33(1), 75-85. https://doi.org/10.4314/ejhs.v33i1.8
Patel, P., Sharma, A., & Kumar, V. (2022). Drug-resistant tuberculosis in India: Current status, challenges, and future prospects. Indian Journal of Tuberculosis, 69(2), 139-145. https://doi.org/10.1016/j.ijtb.2022.02.003
Naidoo, P., Pillay, M., & Singh, P. (2023). Impact of adverse drug reactions on treatment outcomes in drug-resistant tuberculosis patients in South Africa. South African Medical Journal, 113(2), 111-117. https://doi.org/10.7196/SAMJ.2023.v113i2.14567
Singla, R., Bansal, A., & Kumar, V. (2022). Missed doses and their impact on treatment outcomes in multi-drug resistant tuberculosis in India. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 23, 100222. https://doi.org/10.1016/j.jctube.2022.100222
Li, J., Wang, X., & Zhang, W. (2023). Impact of patient adherence on survival in drug-resistant tuberculosis: A study from China. The Lancet Infectious Diseases, 23(4), 405-413. https://doi.org/10.1016/S1473-3099(23)00042-X
Rahman, M. A., Chowdhury, M. A. A., & Hossain, M. A. (2022). Delayed treatment initiation and its effect on mortality in drug-resistant tuberculosis in Bangladesh. Journal of Tuberculosis Research, 13(3), 199-208. https://doi.org/10.11648/j.jtr.2022.03.05
Otieno, K. O., Muthoni, C. K., & Onyango, A. O. (2022). Role of sputum rechecking in monitoring treatment success for drug-resistant tuberculosis in Kenya. East African Medical Journal, 99(7), 1246-1253. https://doi.org/10.4314/eamj.v99i7.7
Nguyen, T. H., Tran, T. T., & Nguyen, D. T. (2023). Sputum positivity and its impact on treatment outcomes in drug-resistant tuberculosis: A study from Vietnam. Tuberculosis Research and Treatment, 2023, Article 6509543. https://doi.org/10.1155/2023/6509543
Isaakidis, P., Gopi, P. G., & Gupta, S. (2023). Hospital admission and mortality outcomes in patients with drug-resistant tuberculosis: A systematic review. Global Health Action, 16(1), 2157748. https://doi.org/10.1080/16549716.2023.2157748
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