A Retrospective Study of Correlation of PAP Smear with Cervical Biopsy in Malignant and Non-malignant Lesions of Cervix in Our Tertiary Hospital at Hapur Region

Abstract

Background: Papanicolaou (PAP) smear is a simple, non invasive and cost effective method for detection of
precancerous changes in the cervix. It is highly effective screening test for the detection of cervical neoplastic
changes so that treatment can be started promptly and thus development of invasive cancer can be prevented.
Aim: To study the correlation between PAP smear and cervical biopsy in malignant and non malignant lesions of
cervix.
Materials and Methods: Retrospective cross-sectional study was conducted in our teaching hospital at Hapur
Region. It included all cases between Ist November 2020 and 31st October 2021 in which both PAP smear and
cervical biopsy were done. Cyto-histopathological correlation was done.
Results: Out of the 188 cases, on PAP smears 85% of cases were reported as inflammatory smears. Premalignant
lesions like LSIL and HSIL were reported in 5.81% and 4.2% of cases respectively.1.0% of cases were directly
diagnosed as SCC. 3.1% of cases were reported as ASCUS. Cytohistopathological correlation was done. Sensitivity
in the present study was 81.3%, Specificity was 92%. Positive predictive value and negative predictive value were
77.6% and 86.5% respectively. Diagnostic accuracy of Pap smear in the present study was 84.5%.